DegronMD

Uniprot ID: Q9UMN6

Source protein: Histone-lysine N-methyltransferase 2B

Source gene: KMT2B

Class: DEG_SPOP_SBC_1

Location: 515:519

E3 ligase: SPOP

DEGRON score: 0.9463

ASA_SCORE: 97.36

COIL: 0.9016

CONS_SCORE: 0.3132

DSS_SCORE: 0.5763

HELIX: 0.0754

FCONS_SCORE: 0.8226

RIG_SCORE: 0.7588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K516E	TCGA-CU-A0YO	BLCA	TCGA	PKSTT	DEG_SPOP_SBC_1	0.591
p.K516E	DO466	BLCA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.591
p.K516Q	TCGA-D1-A17L	UCEC	TCGA	PKSTT	DEG_SPOP_SBC_1	0.5833
p.K516Q	DO40847	UCEC	ICGC	PKSTT	DEG_SPOP_SBC_1	0.5833
p.A514S	TCGA-VS-A9UM	CESC	TCGA	PKSTT	DEG_SPOP_SBC_1	0.3056
p.A514S	DO51644	CESC	ICGC	PKSTT	DEG_SPOP_SBC_1	0.3056
p.R525W	DO222427	BTCA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.1667
p.R525W	SIDM00839	Colorectal Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	0.1667
p.R525W	ACH-000950	Colon/Colorectal Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	0.1667
p.R525W	LoVo	large_intestine	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.1667
p.R525L	DO229035	LICA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.1667
p.P515S	DO220911	MELA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SPOP_SBC_1	376:380	PKSTT	SPOP	0.9058	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	1518:1522	PKSTT	SPOP	0.7644	More...
Q52LJ0	Protein FAM98B	DEG_SPOP_SBC_1	160:164	PKSTT	SPOP	0.9796	More...
Q9BZW7	Testis-specific gene 10 protein	DEG_SPOP_SBC_1	89:93	PKSTT	SPOP	0.765	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	515:519	PKSTT	SPOP	0.9463	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	329:333	PKSTT	SPOP	0.828	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1324:1328	PKSTT	SPOP	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons