DegronMD - P07359(GP1BA)

FUNCTION: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

GO - Biological processes (BP): blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; fibrinolysis [GO:0042730]; megakaryocyte development [GO:0035855]; platelet activation [GO:0030168]; p... View more >>

GO - Molecular function (MF): thrombin-activated receptor activity [GO:0015057]

GO - Cellular component (CC): anchored component of external side of plasma membrane [GO:0031362]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glycoprotein Ib-IX-V complex [GO:1990779]; integral component of plasma membrane [GO:0005887]; memb... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P393L	DO233784	GACA	ICGC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation altering degron motif	0.7582
p.V440M	NUGC-3	stomach	COSMIC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation altering degron motif	0.7208
p.T383A	DO220886	MELA	ICGC	PTPSPT	DEG_SCF_FBW7_1	382:387	Mutation altering degron motif	0.7139
p.T379I	DO233732	GACA	ICGC	PKSTT	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7078
p.T453P	DO229253	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation altering degron motif	0.7031
p.T161M	DO223130	ESCA	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.6312
p.T161M	DO231075	LUSC	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.6312
p.P408T	DO50717	ORCA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation altering degron motif	0.5919
p.A396T	TCGA-A5-A0G2	UCEC	TCGA	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.A396T	DO41235	UCEC	ICGC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.A396T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.A396T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.A396T	ACH-000942	Leukemia	CCLE	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.T401I	TCGA-HE-7129	KIRP	TCGA	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.3056
p.T401I	DO20786	KIRP	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.3056
p.S441P	DO223122	ESCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.S441P	DO228947	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.S441P	DO228949	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.S441P	DO229232	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.S441P	DO229242	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 96 entries

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Kaplan plot for GP1BA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GP1BA

UniProt ID: P07359

Entrez ID: 2811

Protein name: Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (Antigen CD42b-alpha) (CD antigen CD42b) [Cleaved into: Glycocalicin]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GP1BA in