DegronMD - P07359(GP1BA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P411T	TCGA-26-5139	GBM	TCGA	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.2778
p.P411T	TCGA-26-5139	GBM	TCGA	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.0556
p.P411T	DO12358	GBM	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.2778
p.P411T	DO12358	GBM	ICGC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.0556
p.A396T	TCGA-A5-A0G2	UCEC	TCGA	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.A396T	TCGA-A5-A0G2	UCEC	TCGA	PTPSPT	DEG_SCF_FBW7_1	382:387	Mutation rewiring degron network	0.0833
p.A396T	TCGA-A5-A0G2	UCEC	TCGA	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.1667
p.A396T	DO41235	UCEC	ICGC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.A396T	DO41235	UCEC	ICGC	PTPSPT	DEG_SCF_FBW7_1	382:387	Mutation rewiring degron network	0.0833
p.A396T	DO41235	UCEC	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.1667
p.A396T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.A396T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PTPSPT	DEG_SCF_FBW7_1	382:387	Mutation rewiring degron network	0.0833
p.A396T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.1667
p.A396T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.A396T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PTPSPT	DEG_SCF_FBW7_1	382:387	Mutation rewiring degron network	0.0833
p.A396T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.1667
p.A396T	ACH-000942	Leukemia	CCLE	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.3056
p.A396T	ACH-000942	Leukemia	CCLE	PTPSPT	DEG_SCF_FBW7_1	382:387	Mutation rewiring degron network	0.0833
p.A396T	ACH-000942	Leukemia	CCLE	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.1667
p.L155M	TCGA-B2-4102	KIRC	TCGA	LTPTPKLE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1944
p.L155M	DO18839	KIRC	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1944
p.S461I	TCGA-B5-A0JN	UCEC	TCGA	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.1111
p.S461I	TCGA-B5-A0JN	UCEC	TCGA	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.0556
p.S461I	DO41943	UCEC	ICGC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.1111
p.S461I	DO41943	UCEC	ICGC	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.0556
p.V485I	TCGA-CM-5861	COAD	TCGA	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.1111
p.V485I	DO7918	COAD	ICGC	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.1111
p.E351K	TCGA-EE-A2MT	SKCM	TCGA	PRWTPNFT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1667
p.E351K	DO38051	SKCM	ICGC	PRWTPNFT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1667
p.A418T	TCGA-FP-A4BF	STAD	TCGA	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.0833
p.A418T	TCGA-FP-A4BF	STAD	TCGA	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.25
p.A418T	DO47775	STAD	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.0833
p.A418T	DO47775	STAD	ICGC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.25
p.A418T	SIDM00150	Colorectal Carcinoma	GDSC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.0833
p.A418T	SIDM00150	Colorectal Carcinoma	GDSC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.25
p.A418T	KM12	large intestine	COSMIC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.0833
p.A418T	KM12	large intestine	COSMIC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.25
p.T401I	TCGA-HE-7129	KIRP	TCGA	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.1667
p.T401I	TCGA-HE-7129	KIRP	TCGA	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.3056
p.T401I	DO20786	KIRP	ICGC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.1667
p.T401I	DO20786	KIRP	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.3056
p.S441P	DO223122	ESCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.S441P	DO223122	ESCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.1667
p.S441P	DO228947	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.S441P	DO228947	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.1667
p.S441P	DO228949	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.S441P	DO228949	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.1667
p.S441P	DO229232	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.S441P	DO229232	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.1667
p.S441P	DO229242	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.S441P	DO229242	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.1667
p.T161M	DO223130	ESCA	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.6312
p.T161M	DO231075	LUSC	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.6312
p.F355S	DO233259	GACA	ICGC	PRWTPNFT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.2778
p.F355S	DO233259	GACA	ICGC	FTLHME	LIG_APCC_ABBA_1	363:368	Mutation rewiring degron network	0.1111
p.P393L	DO233784	GACA	ICGC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation altering degron motif	0.7582
p.T379I	DO233732	GACA	ICGC	PKSTT	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7078
p.L176V	DO228215	LICA	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.0833
p.M399T	DO228937	LICA	ICGC	SPTTSEPVPEP	DEG_COP1_1	385:395	Mutation rewiring degron network	0.2222
p.M399T	DO228937	LICA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.25
p.S415P	DO228947	LICA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.1667
p.S415P	DO228947	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.1667
p.S415P	DO229216	THCA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.1667
p.S415P	DO229216	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.1667
p.E347D	DO23330	LINC	ICGC	PRWTPNFT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.0556
p.T383A	DO220886	MELA	ICGC	PTPSPT	DEG_SCF_FBW7_1	382:387	Mutation altering degron motif	0.7139
p.P408T	DO50717	ORCA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation altering degron motif	0.5919
p.T453P	DO229253	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation altering degron motif	0.7031
p.A418P	DO229264	THCA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.0833
p.A418P	DO229264	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.25
p.S420R	DO229234	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.3056
p.S428P	DO229242	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.3056
p.S428P	DO229242	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1667
p.V485A	SIDM02059	Colorectal Carcinoma	GDSC	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.1111
p.V466M	SIDM00572	Gastric Carcinoma	GDSC	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.1944
p.V466M	ACH-000911	Gastric Cancer	CCLE	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.1944
p.V466M	NUGC-3	stomach	COSMIC	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.1944
p.A459T	SIDM00657	Acute Myeloid Leukemia	GDSC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.1667
p.E351Q	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRWTPNFT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1667
p.E351Q	ACH-002253	Lymphoma	CCLE	PRWTPNFT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1667
p.E351Q	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PRWTPNFT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1667
p.A444T	SIDM00150	Colorectal Carcinoma	GDSC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2222
p.A444T	SIDM00150	Colorectal Carcinoma	GDSC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.25
p.A444T	KM12	large intestine	COSMIC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2222
p.A444T	KM12	large intestine	COSMIC	PTTPEPT	DEG_SCF_FBW7_1	447:453	Mutation rewiring degron network	0.25
p.V466A	SIDM01617	Endometrial Carcinoma	GDSC	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.1944
p.V466A	ACH-000994	Endometrial/Uterine Cancer	CCLE	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.1944
p.P411L	SIDM01591	Breast Carcinoma	GDSC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.2778
p.P411L	SIDM01591	Breast Carcinoma	GDSC	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.0556
p.P411L	ACH-000540	Non-Cancerous	CCLE	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.2778
p.P411L	ACH-000540	Non-Cancerous	CCLE	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.0556
p.P411L	ACH-001389	Breast Cancer	CCLE	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.2778
p.P411L	ACH-001389	Breast Cancer	CCLE	PTTPEPT	DEG_SCF_FBW7_1	421:427	Mutation rewiring degron network	0.0556
p.V440M	NUGC-3	stomach	COSMIC	PTTPEPT	DEG_SCF_FBW7_1	434:440	Mutation altering degron motif	0.7208
p.H485N	KYSE-410	oesophagus	COSMIC	LITPKST	DEG_SCF_FBW7_1	471:477	Mutation rewiring degron network	0.1111
p.T410P	EFO-27	ovary	COSMIC	LEPTPSPT	DEG_SCF_FBW7_1	402:409	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GP1BA

UniProt ID: P07359

Entrez ID: 2811

Protein name: Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (Antigen CD42b-alpha) (CD antigen CD42b) [Cleaved into: Glycocalicin]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GP1BA in