DegronMD

Uniprot ID: P07359

Source protein: Platelet glycoprotein Ib alpha chain

Source gene: GP1BA

Class: DEG_SCF_FBW7_2

Location: 160:167

E3 ligase: FBXW7

DEGRON score: 0.8719

ASA_SCORE: 61.225

COIL: 0.9569

CONS_SCORE: 0.4189

DSS_SCORE: 0.3632

HELIX: 0.022

FCONS_SCORE: 0.7058

RIG_SCORE: 0.7709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L155M	TCGA-B2-4102	KIRC	TCGA	LTPTPKLE	DEG_SCF_FBW7_2	0.1944
p.L155M	DO18839	KIRC	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	0.1944
p.T161M	DO223130	ESCA	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	0.6312
p.T161M	DO231075	LUSC	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	0.6312
p.L176V	DO228215	LICA	ICGC	LTPTPKLE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_2	160:167	LTPTPKLE	FBXW7	0.8719	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons