DegronMD

Uniprot ID: P07359

Source protein: Platelet glycoprotein Ib alpha chain

Source gene: GP1BA

Class: DEG_COP1_1

Location: 385:395

E3 ligase: COP1

DEGRON score: 0.8503

ASA_SCORE: 87.5909

COIL: 0.8684

CONS_SCORE: 0.3993

DSS_SCORE: 0.8458

HELIX: 0.0166

FCONS_SCORE: 1.2082

RIG_SCORE: 0.5524

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P393L	DO233784	GACA	ICGC	SPTTSEPVPEP	DEG_COP1_1	0.7582
p.A396T	TCGA-A5-A0G2	UCEC	TCGA	SPTTSEPVPEP	DEG_COP1_1	0.3056
p.A396T	DO41235	UCEC	ICGC	SPTTSEPVPEP	DEG_COP1_1	0.3056
p.A396T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SPTTSEPVPEP	DEG_COP1_1	0.3056
p.A396T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	SPTTSEPVPEP	DEG_COP1_1	0.3056
p.A396T	ACH-000942	Leukemia	CCLE	SPTTSEPVPEP	DEG_COP1_1	0.3056
p.M399T	DO228937	LICA	ICGC	SPTTSEPVPEP	DEG_COP1_1	0.2222
p.T401I	TCGA-HE-7129	KIRP	TCGA	SPTTSEPVPEP	DEG_COP1_1	0.1667
p.T401I	DO20786	KIRP	ICGC	SPTTSEPVPEP	DEG_COP1_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_COP1_1	385:395	SPTTSEPVPEP	COP1	0.8503	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons