DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SPTTSEPVPEP
Uniprot ID:
P07359
Source protein:
Platelet glycoprotein Ib alpha chain
Source gene:
GP1BA
Class:
DEG_COP1_1
Location:
385:395
E3 ligase:
COP1
DEGRON score:
0.8503
ASA_SCORE:
87.5909
COIL:
0.8684
CONS_SCORE:
0.3993
DSS_SCORE:
0.8458
HELIX:
0.0166
FCONS_SCORE:
1.2082
RIG_SCORE:
0.5524
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A396T
TCGA-A5-A0G2
UCEC
TCGA
SPTTSEPVPEP
DEG_COP1_1
0.3056
p.A396T
DO41235
UCEC
ICGC
SPTTSEPVPEP
DEG_COP1_1
0.3056
p.A396T
SIDM01263
T-Lymphoblastic Leukemia
GDSC
SPTTSEPVPEP
DEG_COP1_1
0.3056
p.A396T
SIDM01618
B-Lymphoblastic Leukemia
GDSC
SPTTSEPVPEP
DEG_COP1_1
0.3056
p.A396T
ACH-000942
Leukemia
CCLE
SPTTSEPVPEP
DEG_COP1_1
0.3056
p.T401I
TCGA-HE-7129
KIRP
TCGA
SPTTSEPVPEP
DEG_COP1_1
0.1667
p.T401I
DO20786
KIRP
ICGC
SPTTSEPVPEP
DEG_COP1_1
0.1667
p.P393L
DO233784
GACA
ICGC
SPTTSEPVPEP
DEG_COP1_1
0.7582
p.M399T
DO228937
LICA
ICGC
SPTTSEPVPEP
DEG_COP1_1
0.2222
Drug responses associated with GP1BA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SPTTSEPVPEP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P07359
Platelet glycoprotein Ib alpha chain
DEG_COP1_1
385:395
SPTTSEPVPEP
COP1
0.8503
More...