DegronMD

Uniprot ID: P07359

Source protein: Platelet glycoprotein Ib alpha chain

Source gene: GP1BA

Class: DEG_SCF_FBW7_1

Location: 447:453

E3 ligase: FBXW7

DEGRON score: 0.9405

ASA_SCORE: 91.9857

COIL: 0.953

CONS_SCORE: 0.3737

DSS_SCORE: 0.8034

HELIX: 0.0099

FCONS_SCORE: 1.1447

RIG_SCORE: 0.5602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S461I	TCGA-B5-A0JN	UCEC	TCGA	PTTPEPT	DEG_SCF_FBW7_1	0.1111
p.S461I	DO41943	UCEC	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.1111
p.S441P	DO223122	ESCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.1667
p.S441P	DO228947	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.1667
p.S441P	DO228949	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.1667
p.S441P	DO229232	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.1667
p.S441P	DO229242	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.1667
p.T453P	DO229253	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.7031
p.A459T	SIDM00657	Acute Myeloid Leukemia	GDSC	PTTPEPT	DEG_SCF_FBW7_1	0.1667
p.A444T	SIDM00150	Colorectal Carcinoma	GDSC	PTTPEPT	DEG_SCF_FBW7_1	0.25
p.A444T	KM12	large_intestine	COSMIC	PTTPEPT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	421:427	PTTPEPT	FBXW7	0.9819	More...
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	434:440	PTTPEPT	FBXW7	0.7405	More...
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	447:453	PTTPEPT	FBXW7	0.9405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons