DegronMD

Uniprot ID: P07359

Source protein: Platelet glycoprotein Ib alpha chain

Source gene: GP1BA

Class: DEG_SCF_FBW7_1

Location: 421:427

E3 ligase: FBXW7

DEGRON score: 0.9819

ASA_SCORE: 90.6571

COIL: 0.9437

CONS_SCORE: 0.4532

DSS_SCORE: 0.9019

HELIX: 0.01

FCONS_SCORE: 1.2687

RIG_SCORE: 0.4537

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P411T	TCGA-26-5139	GBM	TCGA	PTTPEPT	DEG_SCF_FBW7_1	0.0556
p.P411T	DO12358	GBM	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.0556
p.A418T	TCGA-FP-A4BF	STAD	TCGA	PTTPEPT	DEG_SCF_FBW7_1	0.25
p.A418T	DO47775	STAD	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.25
p.A418T	SIDM00150	Colorectal Carcinoma	GDSC	PTTPEPT	DEG_SCF_FBW7_1	0.25
p.A418T	KM12	large_intestine	COSMIC	PTTPEPT	DEG_SCF_FBW7_1	0.25
p.S415P	DO228947	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.1667
p.S415P	DO229216	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.1667
p.A418P	DO229264	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.25
p.S420R	DO229234	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.3056
p.S428P	DO229242	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.3056
p.P411L	SIDM01591	Breast Carcinoma	GDSC	PTTPEPT	DEG_SCF_FBW7_1	0.0556
p.P411L	ACH-000540	Non-Cancerous	CCLE	PTTPEPT	DEG_SCF_FBW7_1	0.0556
p.P411L	ACH-001389	Breast Cancer	CCLE	PTTPEPT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	421:427	PTTPEPT	FBXW7	0.9819	More...
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	434:440	PTTPEPT	FBXW7	0.7405	More...
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	447:453	PTTPEPT	FBXW7	0.9405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons