DegronMD

Uniprot ID: P07359

Source protein: Platelet glycoprotein Ib alpha chain

Source gene: GP1BA

Class: DEG_SCF_FBW7_1

Location: 434:440

E3 ligase: FBXW7

DEGRON score: 0.7405

ASA_SCORE: 86.6857

COIL: 0.9424

CONS_SCORE: 0.3592

DSS_SCORE: 0.8938

HELIX: 0.0121

FCONS_SCORE: 0.9585

RIG_SCORE: 0.4638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S441P	DO223122	ESCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.3056
p.S441P	DO228947	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.3056
p.S441P	DO228949	LICA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.3056
p.S441P	DO229232	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.3056
p.S441P	DO229242	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.3056
p.S428P	DO229242	THCA	ICGC	PTTPEPT	DEG_SCF_FBW7_1	0.1667
p.A444T	SIDM00150	Colorectal Carcinoma	GDSC	PTTPEPT	DEG_SCF_FBW7_1	0.2222
p.A444T	KM12	large_intestine	COSMIC	PTTPEPT	DEG_SCF_FBW7_1	0.2222
p.V440M	NUGC-3	stomach	COSMIC	PTTPEPT	DEG_SCF_FBW7_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	421:427	PTTPEPT	FBXW7	0.9819	More...
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	434:440	PTTPEPT	FBXW7	0.7405	More...
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	447:453	PTTPEPT	FBXW7	0.9405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons