DegronMD

Uniprot ID: P07359

Source protein: Platelet glycoprotein Ib alpha chain

Source gene: GP1BA

Class: DEG_SCF_FBW7_1

Location: 471:477

E3 ligase: FBXW7

DEGRON score: 0.632

ASA_SCORE: 90.0286

COIL: 0.8031

CONS_SCORE: 0.251

DSS_SCORE: 0.3433

HELIX: 0.0199

FCONS_SCORE: 0.8047

RIG_SCORE: 0.7787

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S461I	TCGA-B5-A0JN	UCEC	TCGA	LITPKST	DEG_SCF_FBW7_1	0.0556
p.S461I	DO41943	UCEC	ICGC	LITPKST	DEG_SCF_FBW7_1	0.0556
p.V485I	TCGA-CM-5861	COAD	TCGA	LITPKST	DEG_SCF_FBW7_1	0.1111
p.V485I	DO7918	COAD	ICGC	LITPKST	DEG_SCF_FBW7_1	0.1111
p.V485A	SIDM02059	Colorectal Carcinoma	GDSC	LITPKST	DEG_SCF_FBW7_1	0.1111
p.V466M	SIDM00572	Gastric Carcinoma	GDSC	LITPKST	DEG_SCF_FBW7_1	0.1944
p.V466M	ACH-000911	Gastric Cancer	CCLE	LITPKST	DEG_SCF_FBW7_1	0.1944
p.V466M	NUGC-3	stomach	COSMIC	LITPKST	DEG_SCF_FBW7_1	0.1944
p.V466A	SIDM01617	Endometrial Carcinoma	GDSC	LITPKST	DEG_SCF_FBW7_1	0.1944
p.V466A	ACH-000994	Endometrial/Uterine Cancer	CCLE	LITPKST	DEG_SCF_FBW7_1	0.1944
p.H485N	KYSE-410	oesophagus	COSMIC	LITPKST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	471:477	LITPKST	FBXW7	0.632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons