DegronMD

Uniprot ID: P07359

Source protein: Platelet glycoprotein Ib alpha chain

Source gene: GP1BA

Class: DEG_SCF_FBW7_1

Location: 402:409

E3 ligase: FBXW7

DEGRON score: 0.8062

ASA_SCORE: 87.4625

COIL: 0.9323

CONS_SCORE: 0.3469

DSS_SCORE: 0.8976

HELIX: 0.0121

FCONS_SCORE: 1.0032

RIG_SCORE: 0.516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P411T	TCGA-26-5139	GBM	TCGA	LEPTPSPT	DEG_SCF_FBW7_1	0.2778
p.P411T	DO12358	GBM	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	0.2778
p.A396T	TCGA-A5-A0G2	UCEC	TCGA	LEPTPSPT	DEG_SCF_FBW7_1	0.1667
p.A396T	DO41235	UCEC	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	0.1667
p.A396T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LEPTPSPT	DEG_SCF_FBW7_1	0.1667
p.A396T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LEPTPSPT	DEG_SCF_FBW7_1	0.1667
p.A396T	ACH-000942	Leukemia	CCLE	LEPTPSPT	DEG_SCF_FBW7_1	0.1667
p.A418T	TCGA-FP-A4BF	STAD	TCGA	LEPTPSPT	DEG_SCF_FBW7_1	0.0833
p.A418T	DO47775	STAD	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	0.0833
p.A418T	SIDM00150	Colorectal Carcinoma	GDSC	LEPTPSPT	DEG_SCF_FBW7_1	0.0833
p.A418T	KM12	large_intestine	COSMIC	LEPTPSPT	DEG_SCF_FBW7_1	0.0833
p.T401I	TCGA-HE-7129	KIRP	TCGA	LEPTPSPT	DEG_SCF_FBW7_1	0.3056
p.T401I	DO20786	KIRP	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	0.3056
p.M399T	DO228937	LICA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	0.25
p.S415P	DO228947	LICA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	0.1667
p.S415P	DO229216	THCA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	0.1667
p.P408T	DO50717	ORCA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	0.5919
p.A418P	DO229264	THCA	ICGC	LEPTPSPT	DEG_SCF_FBW7_1	0.0833
p.P411L	SIDM01591	Breast Carcinoma	GDSC	LEPTPSPT	DEG_SCF_FBW7_1	0.2778
p.P411L	ACH-000540	Non-Cancerous	CCLE	LEPTPSPT	DEG_SCF_FBW7_1	0.2778
p.P411L	ACH-001389	Breast Cancer	CCLE	LEPTPSPT	DEG_SCF_FBW7_1	0.2778
p.T410P	EFO-27	ovary	COSMIC	LEPTPSPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	402:409	LEPTPSPT	FBXW7	0.8062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons