DegronMD

Uniprot ID: P07359

Source protein: Platelet glycoprotein Ib alpha chain

Source gene: GP1BA

Class: DEG_SCF_FBW7_1

Location: 357:364

E3 ligase: FBXW7

DEGRON score: 0.9288

ASA_SCORE: 89.525

COIL: 0.8449

CONS_SCORE: 0.3195

DSS_SCORE: 0.614

HELIX: 0.0293

FCONS_SCORE: 0.9863

RIG_SCORE: 0.7329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E351K	TCGA-EE-A2MT	SKCM	TCGA	PRWTPNFT	DEG_SCF_FBW7_1	0.1667
p.E351K	DO38051	SKCM	ICGC	PRWTPNFT	DEG_SCF_FBW7_1	0.1667
p.F355S	DO233259	GACA	ICGC	PRWTPNFT	DEG_SCF_FBW7_1	0.2778
p.E347D	DO23330	LINC	ICGC	PRWTPNFT	DEG_SCF_FBW7_1	0.0556
p.E351Q	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRWTPNFT	DEG_SCF_FBW7_1	0.1667
p.E351Q	ACH-002253	Lymphoma	CCLE	PRWTPNFT	DEG_SCF_FBW7_1	0.1667
p.E351Q	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRWTPNFT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	357:364	PRWTPNFT	FBXW7	0.9288	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons