DegronMD

Uniprot ID: P07359

Source protein: Platelet glycoprotein Ib alpha chain

Source gene: GP1BA

Class: DEG_SCF_FBW7_1

Location: 382:387

E3 ligase: FBXW7

DEGRON score: 0.9633

ASA_SCORE: 83.55

COIL: 0.9125

CONS_SCORE: 0.3971

DSS_SCORE: 0.8106

HELIX: 0.0112

FCONS_SCORE: 1.1727

RIG_SCORE: 0.5248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A396T	TCGA-A5-A0G2	UCEC	TCGA	PTPSPT	DEG_SCF_FBW7_1	0.0833
p.A396T	DO41235	UCEC	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.0833
p.A396T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PTPSPT	DEG_SCF_FBW7_1	0.0833
p.A396T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PTPSPT	DEG_SCF_FBW7_1	0.0833
p.A396T	ACH-000942	Leukemia	CCLE	PTPSPT	DEG_SCF_FBW7_1	0.0833
p.T383A	DO220886	MELA	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	382:387	PTPSPT	FBXW7	0.9633	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SCF_FBW7_1	28:33	PTPSPT	FBXW7	0.7611	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons