DegronMD

Uniprot ID: P08575

Source protein: Receptor-type tyrosine-protein phosphatase C

Source gene: PTPRC

Class: DEG_SCF_FBW7_1

Location: 28:33

E3 ligase: FBXW7

DEGRON score: 0.7611

ASA_SCORE: 86.2167

COIL: 0.9372

CONS_SCORE: 0.3328

DSS_SCORE: 0.4876

HELIX: 0.0188

FCONS_SCORE: 1.0238

RIG_SCORE: 0.6452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V21L	TCGA-16-1045	GBM	TCGA	PTPSPT	DEG_SCF_FBW7_1	0.1389
p.S42G	TCGA-AG-A02N	READ	TCGA	PTPSPT	DEG_SCF_FBW7_1	0.0833
p.V23M	TCGA-BR-8078	STAD	TCGA	PTPSPT	DEG_SCF_FBW7_1	0.1944
p.G25R	TCGA-D3-A8GV	SKCM	TCGA	PTPSPT	DEG_SCF_FBW7_1	0.25
p.E20G	TCGA-DF-A2KN	UCEC	TCGA	PTPSPT	DEG_SCF_FBW7_1	0.1111
p.V19L	DO11800	GBM	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.0833
p.L43V	DO45450	LUSC	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.0556
p.Q37K	DO35132	PACA	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.2222
p.S40G	DO37146	READ	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.1389
p.P42L	DO47362	SKCM	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.0833
p.P42S	DO51281	SKCM	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.0833
p.G23R	DO219477	SKCM	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.1944
p.E18G	DO223282	UCEC	ICGC	PTPSPT	DEG_SCF_FBW7_1	0.0556
p.K39T	SIDM01155	Glioma	GDSC	PTPSPT	DEG_SCF_FBW7_1	0.2778
p.K39T	SW1088	central_nervous_system	COSMIC	PTPSPT	DEG_SCF_FBW7_1	0.2778
p.V23A	ACH-002055	Lymphoma	CCLE	PTPSPT	DEG_SCF_FBW7_1	0.1944
p.E41K	LB373-MEL-D	skin	COSMIC	PTPSPT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SCF_FBW7_1	382:387	PTPSPT	FBXW7	0.9633	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SCF_FBW7_1	28:33	PTPSPT	FBXW7	0.7611	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons