DegronMD - P08575(PTPRC)

GO - Biological processes (BP): B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; bone marrow development [GO:0048539]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell cycle phase transition [GO:0044770]; cell surface receptor signaling pathway [GO:0007166]; cellular response to extracellular stimulus [GO:0031668]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; DN2 thymocyte differentiation [GO:1904155]; hematopoietic progenitor cell differentiation [GO:0002244]; heterotypic cell-cell adhesion [GO:0034113]; leukocyte cell-cell adhesion [GO:0007159]; natural killer cell differentiation [GO:0001779]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative thymic T cell selection [GO:0045060]; plasma membrane raft distribution [GO:0044855]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein tyrosine phosphatase activity [GO:1903615]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive thymic T cell selection [GO:0045059]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of interleukin-8 production [GO:0032677]; regulation of phagocytosis [GO:0050764]; regulation of protein tyrosine kinase activity [GO:0061097]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; release of sequestered calcium ion into cytosol [GO:0051209]; response to gamma radiation [GO:0010332]; stem cell development [GO:0048864]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V21L	TCGA-16-1045	GBM	TCGA	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1389
p.P162Q	TCGA-24-1616	OV	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.P162Q	DO30150	OV	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.G210V	TCGA-61-2096	OV	TCGA	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.G210V	SIDM00296	Small Cell Lung Carcinoma	GDSC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.G210V	ACH-002051	Lung Cancer	CCLE	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.G210V	LU-134-A	lung	COSMIC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.T168A	TCGA-A5-A0G2	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7139
p.S42G	TCGA-AG-A02N	READ	TCGA	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0833
p.H174Y	TCGA-AP-A1DK	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.A220V	TCGA-AP-A1DK	UCEC	TCGA	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.P162S	TCGA-BF-AAOX	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.P208S	TCGA-BF-AAP2	SKCM	TCGA	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1944
p.V23M	TCGA-BR-8078	STAD	TCGA	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1944
p.G210E	TCGA-D3-A3MU	SKCM	TCGA	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.G210E	TCGA-EB-A4IS	SKCM	TCGA	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.G25R	TCGA-D3-A8GV	SKCM	TCGA	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.25
p.E20G	TCGA-DF-A2KN	UCEC	TCGA	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1111
p.P162R	TCGA-EX-A3L1	CESC	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.P162R	DO6335	CESC	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.L166S	TCGA-EY-A1GD	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6556
p.L166S	DO42129	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6556
p.S176N	TCGA-FR-A726	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.S176N	DO48665	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.H175Y	TCGA-FS-A1ZC	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.P159S	TCGA-GN-A8LK	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.P159S	DO51259	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.L206V	TCGA-LA-A446	LUSC	TCGA	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1389
p.S177F	TCGA-XF-A9T5	BLCA	TCGA	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.S175F	DO51925	BLCA	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.K203M	DO49760	BLCA	ICGC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.K163T	DO1285	BRCA	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.T167I	DO222574	BTCA	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7078
p.T167I	DO223286	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7078
p.K203R	DO234266	ESAD	ICGC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.F215L	DO233796	GACA	ICGC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.6981
p.V19L	DO11800	GBM	ICGC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0833
p.T156I	DO22427	LGG	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.T169N	DO231976	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7055
p.F226Y	DO50890	LICA	ICGC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0833
p.S176G	DO50840	LIRI	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.C170S	DO23723	LUAD	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.I158N	DO26838	LUSC	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.L43V	DO45450	LUSC	ICGC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0556
p.N174S	DO231639	NBL	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.Q37K	DO35132	PACA	ICGC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.2222
p.S40G	DO37146	READ	ICGC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1389
p.A218T	DO37042	READ	ICGC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.A218T	DO41133	UCEC	ICGC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.Y210H	DO37372	READ	ICGC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.H173Y	DO37487	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.P42L	DO47362	SKCM	ICGC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0833
p.P160S	DO223907	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.P42S	DO51281	SKCM	ICGC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0833
p.G23R	DO219477	SKCM	ICGC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1944
p.R178I	DO43306	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.H172Y	DO42033	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.E18G	DO223282	UCEC	ICGC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0556
p.K161Q	DO41542	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.T166A	DO41235	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7139
p.T217S	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.6005
p.T217S	ACH-000733	Lung Cancer	CCLE	VISTT	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.6005
p.T217S	NCI-H1838	lung	COSMIC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.6005
p.A155T	SIDM00889	Cervical Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.A155T	ACH-001333	Cervical Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.A155T	C-33-A	cervix	COSMIC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.T227R	SIDM00485	Oral Cavity Carcinoma	GDSC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.T227R	ACH-000794	Head and Neck Cancer	CCLE	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.T227R	BICR22	upper aerodigestive tract	COSMIC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.K39T	SIDM01155	Glioma	GDSC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation substituting flanking lysine	0.2778
p.K39T	SW1088	central nervous system	COSMIC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation substituting flanking lysine	0.2778
p.P159H	ACH-001061	Colon/Colorectal Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.V23A	ACH-002055	Lymphoma	CCLE	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1944
p.E41K	LB373-MEL-D	skin	COSMIC	PTPSPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1111
p.A220T	LK-2	lung	COSMIC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.E168K	LU-65	lung	COSMIC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7022
p.E168K	HSC-4	upper aerodigestive tract	COSMIC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7022
p.E168K	LU-139	lung	COSMIC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7022
p.E168K	HO-1-u-1	upper aerodigestive tract	COSMIC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7022
p.E168K	OCUB-M	breast	COSMIC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7022
p.E168K	TE-9	oesophagus	COSMIC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7022
p.C172Y	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	PLTTT	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.K205T	SNU-C1	large intestine	COSMIC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1111
p.I223S	SNU-81	large intestine	COSMIC	VISTT	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1667

Kaplan plot for PTPRC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRC

UniProt ID: P08575

Entrez ID: 5788

Protein name: Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPRC in