DegronMD

Uniprot ID: P08575

Source protein: Receptor-type tyrosine-protein phosphatase C

Source gene: PTPRC

Class: DEG_SPOP_SBC_1

Location: 213:217

E3 ligase: SPOP

DEGRON score: 0.7771

ASA_SCORE: 73.76

COIL: 0.4918

CONS_SCORE: 0.3442

DSS_SCORE: 0.424

HELIX: 0.0154

FCONS_SCORE: 1.0932

RIG_SCORE: 0.7578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G210V	TCGA-61-2096	OV	TCGA	VISTT	DEG_SPOP_SBC_1	0.25
p.G210V	SIDM00296	Small Cell Lung Carcinoma	GDSC	VISTT	DEG_SPOP_SBC_1	0.25
p.G210V	ACH-002051	Lung Cancer	CCLE	VISTT	DEG_SPOP_SBC_1	0.25
p.G210V	LU-134-A	lung	COSMIC	VISTT	DEG_SPOP_SBC_1	0.25
p.A220V	TCGA-AP-A1DK	UCEC	TCGA	VISTT	DEG_SPOP_SBC_1	0.25
p.P208S	TCGA-BF-AAP2	SKCM	TCGA	VISTT	DEG_SPOP_SBC_1	0.1944
p.G210E	TCGA-D3-A3MU	SKCM	TCGA	VISTT	DEG_SPOP_SBC_1	0.25
p.G210E	TCGA-EB-A4IS	SKCM	TCGA	VISTT	DEG_SPOP_SBC_1	0.25
p.L206V	TCGA-LA-A446	LUSC	TCGA	VISTT	DEG_SPOP_SBC_1	0.1389
p.K203M	DO49760	BLCA	ICGC	VISTT	DEG_SPOP_SBC_1	0.0556
p.K203R	DO234266	ESAD	ICGC	VISTT	DEG_SPOP_SBC_1	0.0556
p.F215L	DO233796	GACA	ICGC	VISTT	DEG_SPOP_SBC_1	0.6981
p.F226Y	DO50890	LICA	ICGC	VISTT	DEG_SPOP_SBC_1	0.0833
p.A218T	DO37042	READ	ICGC	VISTT	DEG_SPOP_SBC_1	0.3056
p.A218T	DO41133	UCEC	ICGC	VISTT	DEG_SPOP_SBC_1	0.3056
p.Y210H	DO37372	READ	ICGC	VISTT	DEG_SPOP_SBC_1	0.25
p.T217S	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	VISTT	DEG_SPOP_SBC_1	0.6005
p.T217S	ACH-000733	Lung Cancer	CCLE	VISTT	DEG_SPOP_SBC_1	0.6005
p.T217S	NCI-H1838	lung	COSMIC	VISTT	DEG_SPOP_SBC_1	0.6005
p.T227R	SIDM00485	Oral Cavity Carcinoma	GDSC	VISTT	DEG_SPOP_SBC_1	0.0556
p.T227R	ACH-000794	Head and Neck Cancer	CCLE	VISTT	DEG_SPOP_SBC_1	0.0556
p.T227R	BICR22	upper_aerodigestive_tract	COSMIC	VISTT	DEG_SPOP_SBC_1	0.0556
p.A220T	LK-2	lung	COSMIC	VISTT	DEG_SPOP_SBC_1	0.25
p.K205T	SNU-C1	large_intestine	COSMIC	VISTT	DEG_SPOP_SBC_1	0.1111
p.I223S	SNU-81	large_intestine	COSMIC	VISTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	213:217	VISTT	SPOP	0.7771	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1161:1165	VISTT	SPOP	0.7988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons