DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_SPOP_SBC_1

Location: 1161:1165

E3 ligase: SPOP

DEGRON score: 0.7988

ASA_SCORE: 87.34

COIL: 0.8536

CONS_SCORE: 0.808

DSS_SCORE: 0.6298

HELIX: 0.0154

FCONS_SCORE: 1.0538

RIG_SCORE: 0.6904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1165M	SIDM00239	Kidney Carcinoma	GDSC	VISTT	DEG_SPOP_SBC_1	0.7423
p.T1165M	OS-RC-2	kidney	COSMIC	VISTT	DEG_SPOP_SBC_1	0.7423
p.P1173S	MCC13	skin	COSMIC	VISTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	213:217	VISTT	SPOP	0.7771	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1161:1165	VISTT	SPOP	0.7988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons