DegronMD

Uniprot ID: P08575

Source protein: Receptor-type tyrosine-protein phosphatase C

Source gene: PTPRC

Class: DEG_SPOP_SBC_1

Location: 165:169

E3 ligase: SPOP

DEGRON score: 0.9751

ASA_SCORE: 75.02

COIL: 0.754

CONS_SCORE: 0.3202

DSS_SCORE: 0.5016

HELIX: 0.0624

FCONS_SCORE: 1.0268

RIG_SCORE: 0.733

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P162Q	TCGA-24-1616	OV	TCGA	PLTTT	DEG_SPOP_SBC_1	0.25
p.P162Q	DO30150	OV	ICGC	PLTTT	DEG_SPOP_SBC_1	0.25
p.T168A	TCGA-A5-A0G2	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.7139
p.H174Y	TCGA-AP-A1DK	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1944
p.P162S	TCGA-BF-AAOX	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	0.25
p.P162R	TCGA-EX-A3L1	CESC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.25
p.P162R	DO6335	CESC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.25
p.L166S	TCGA-EY-A1GD	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.6556
p.L166S	DO42129	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.6556
p.S176N	TCGA-FR-A726	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1389
p.S176N	DO48665	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1389
p.H175Y	TCGA-FS-A1ZC	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1667
p.P159S	TCGA-GN-A8LK	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1667
p.P159S	DO51259	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1667
p.S177F	TCGA-XF-A9T5	BLCA	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1111
p.S175F	DO51925	BLCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1667
p.K163T	DO1285	BRCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2778
p.T167I	DO222574	BTCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7078
p.T167I	DO223286	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7078
p.T156I	DO22427	LGG	ICGC	PLTTT	DEG_SPOP_SBC_1	0.0833
p.T169N	DO231976	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7055
p.S176G	DO50840	LIRI	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1389
p.C170S	DO23723	LUAD	ICGC	PLTTT	DEG_SPOP_SBC_1	0.3056
p.I158N	DO26838	LUSC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1389
p.N174S	DO231639	NBL	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1944
p.H173Y	DO37487	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.P160S	DO223907	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1944
p.R178I	DO43306	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.0833
p.H172Y	DO42033	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.25
p.K161Q	DO41542	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.T166A	DO41235	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7139
p.A155T	SIDM00889	Cervical Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.0556
p.A155T	ACH-001333	Cervical Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	0.0556
p.A155T	C-33-A	cervix	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.0556
p.P159H	ACH-001061	Colon/Colorectal Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	0.1667
p.E168K	LU-65	lung	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.7022
p.E168K	HSC-4	upper_aerodigestive_tract	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.7022
p.E168K	LU-139	lung	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.7022
p.E168K	HO-1-u-1	upper_aerodigestive_tract	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.7022
p.E168K	OCUB-M	breast	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.7022
p.E168K	TE-9	oesophagus	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.7022
p.C172Y	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95206	Protocadherin-8	DEG_SPOP_SBC_1	699:703	PLTTT	SPOP	0.9524	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	165:169	PLTTT	SPOP	0.9751	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1755:1759	PLTTT	SPOP	0.8841	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	743:747	PLTTT	SPOP	0.9993	More...
Q53H47	Histone-lysine N-methyltransferase SETMAR	DEG_SPOP_SBC_1	425:429	PLTTT	SPOP	0.5678	More...
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_SPOP_SBC_1	547:551	PLTTT	SPOP	0.5232	More...
Q8ND30	Liprin-beta-2	DEG_SPOP_SBC_1	804:808	PLTTT	SPOP	0.9988	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8776:8780	PLTTT	SPOP	0.9519	More...
Q9HCM2	Plexin-A4	DEG_SPOP_SBC_1	107:111	PLTTT	SPOP	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTTT

Degron related mutations and impact score

Drug responses associated with PTPRC mutations

All proteins holding degron of PLTTT