DegronMD

Uniprot ID: Q8IVB4

Source protein: Sodium/hydrogen exchanger 9

Source gene: SLC9A9

Class: DEG_SPOP_SBC_1

Location: 547:551

E3 ligase: SPOP

DEGRON score: 0.5232

ASA_SCORE: 77.06

COIL: 0.805

CONS_SCORE: 0.3334

DSS_SCORE: 0.3042

HELIX: 0.125

FCONS_SCORE: 0.9247

RIG_SCORE: 0.7397

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S544Y	TCGA-AA-A010	COAD	TCGA	PLTTT	DEG_SPOP_SBC_1	0.25
p.H543N	TCGA-B0-5096	KIRC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.2222
p.H543N	DO19218	KIRC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.T550A	TCGA-CG-5721	STAD	TCGA	PLTTT	DEG_SPOP_SBC_1	0.7139
p.T550A	DO38192	STAD	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7139
p.P558L	TCGA-CV-7261	HNSC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1389
p.P558L	TCGA-D3-A8GI	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1389
p.P558L	TCGA-DF-A2KU	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1389
p.P558L	DO15062	HNSC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1389
p.P558L	DO50284	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1389
p.P558L	DO223286	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1389
p.P558L	ACH-001075	Lung Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	0.1389
p.P558L	NCI-H292	lung	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.1389
p.S560F	DO233272	GACA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.0833
p.T551K	DO229025	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7306
p.I540V	SIDM00875	Breast Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.1389
p.I540V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95206	Protocadherin-8	DEG_SPOP_SBC_1	699:703	PLTTT	SPOP	0.9524	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	165:169	PLTTT	SPOP	0.9751	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1755:1759	PLTTT	SPOP	0.8841	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	743:747	PLTTT	SPOP	0.9993	More...
Q53H47	Histone-lysine N-methyltransferase SETMAR	DEG_SPOP_SBC_1	425:429	PLTTT	SPOP	0.5678	More...
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_SPOP_SBC_1	547:551	PLTTT	SPOP	0.5232	More...
Q8ND30	Liprin-beta-2	DEG_SPOP_SBC_1	804:808	PLTTT	SPOP	0.9988	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8776:8780	PLTTT	SPOP	0.9519	More...
Q9HCM2	Plexin-A4	DEG_SPOP_SBC_1	107:111	PLTTT	SPOP	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons