DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SPOP_SBC_1

Location: 1755:1759

E3 ligase: SPOP

DEGRON score: 0.8841

ASA_SCORE: 96.88

COIL: 0.9408

CONS_SCORE: 0.2365

DSS_SCORE: 0.7169

HELIX: 0.0106

FCONS_SCORE: 0.9703

RIG_SCORE: 0.6557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1757P	DO48389	BLCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7503
p.A1757P	DO48390	BLCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7503
p.A1757P	DO48370	BLCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7503
p.A1757P	DO229502	SKCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7503
p.A1757P	DO229232	THCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7503
p.G1763S	DO224817	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.G1763S	DO222849	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.G1763S	DO229010	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.G1763S	DO229013	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.G1763S	DO229016	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.G1763S	DO229003	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.G1763S	DO229005	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.V1746L	DO229013	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.0833
p.T1764S	DO229003	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1944
p.Q1765H	DO229051	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1667
p.P1767L	DO26414	LUAD	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1111
p.T1758A	ACH-002139	Kidney Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95206	Protocadherin-8	DEG_SPOP_SBC_1	699:703	PLTTT	SPOP	0.9524	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	165:169	PLTTT	SPOP	0.9751	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1755:1759	PLTTT	SPOP	0.8841	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	743:747	PLTTT	SPOP	0.9993	More...
Q53H47	Histone-lysine N-methyltransferase SETMAR	DEG_SPOP_SBC_1	425:429	PLTTT	SPOP	0.5678	More...
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_SPOP_SBC_1	547:551	PLTTT	SPOP	0.5232	More...
Q8ND30	Liprin-beta-2	DEG_SPOP_SBC_1	804:808	PLTTT	SPOP	0.9988	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8776:8780	PLTTT	SPOP	0.9519	More...
Q9HCM2	Plexin-A4	DEG_SPOP_SBC_1	107:111	PLTTT	SPOP	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons