DegronMD - Q8IVB4(SLC9A9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G624V	TCGA-37-4141	LUSC	TCGA	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624V	TCGA-37-4141	LUSC	TCGA	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1944
p.G624V	DO26862	LUSC	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624V	DO26862	LUSC	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1944
p.G627C	TCGA-38-4632	LUAD	TCGA	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627C	TCGA-38-4632	LUAD	TCGA	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627C	TCGA-86-6851	LUAD	TCGA	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627C	TCGA-86-6851	LUAD	TCGA	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627C	DO23858	LUAD	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627C	DO23858	LUAD	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627C	DO23798	LUAD	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627C	DO23798	LUAD	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627V	TCGA-44-2655	LUAD	TCGA	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627V	TCGA-44-2655	LUAD	TCGA	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627V	DO23557	LUAD	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627V	DO23557	LUAD	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627V	ACH-000929	Lung Cancer	CCLE	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627V	ACH-000929	Lung Cancer	CCLE	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627V	NCI-H2110	lung	COSMIC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627V	NCI-H2110	lung	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.S544Y	TCGA-AA-A010	COAD	TCGA	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.25
p.H543N	TCGA-B0-5096	KIRC	TCGA	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.H543N	DO19218	KIRC	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.T550A	TCGA-CG-5721	STAD	TCGA	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7139
p.T550A	DO38192	STAD	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7139
p.P558L	TCGA-CV-7261	HNSC	TCGA	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P558L	TCGA-D3-A8GI	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P558L	TCGA-DF-A2KU	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P558L	DO15062	HNSC	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P558L	DO50284	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P558L	DO223286	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P558L	ACH-001075	Lung Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P558L	NCI-H292	lung	COSMIC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.E619K	TCGA-D3-A3C7	SKCM	TCGA	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7022
p.E619K	TCGA-D3-A3C7	SKCM	TCGA	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation altering degron motif	0.7022
p.E619K	DO47569	SKCM	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7022
p.E619K	DO47569	SKCM	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation altering degron motif	0.7022
p.G624R	TCGA-DA-A95Z	SKCM	TCGA	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624R	TCGA-DA-A95Z	SKCM	TCGA	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1944
p.G624R	DO219481	SKCM	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624R	DO219481	SKCM	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1944
p.S560F	DO233272	GACA	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.0833
p.T615K	DO229015	LICA	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation altering degron motif	0.8417
p.T551K	DO229025	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7306
p.L607M	DO229009	LICA	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.0556
p.L607M	DO229009	LICA	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1667
p.Q609K	DO23522	LIRI	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1111
p.Q609K	DO23522	LIRI	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.2222
p.Q609K	SIDM00761	Small Cell Lung Carcinoma	GDSC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1111
p.Q609K	SIDM00761	Small Cell Lung Carcinoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.2222
p.Q609K	ACH-000752	Lung Cancer	CCLE	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1111
p.Q609K	ACH-000752	Lung Cancer	CCLE	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.2222
p.Q609K	NCI-H196	lung	COSMIC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1111
p.Q609K	NCI-H196	lung	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.2222
p.D608N	DO229462	SKCA	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.0833
p.D608N	DO229462	SKCA	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1944
p.A603E	SIDM00857	Melanoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.0556
p.A603E	SIDM00820	Kidney Carcinoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.0556
p.A603E	SIDM01193	Glioma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.0556
p.A603E	RCC-ER	kidney	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.0556
p.A603E	U-118-MG	central nervous system	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.0556
p.A603E	G-361	skin	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.0556
p.S612P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation blocking phosphorylation signal	0.6389
p.S612P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation blocking phosphorylation signal	0.75
p.I540V	SIDM00875	Breast Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.I540V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.G630D	SIDM00699	Small Cell Lung Carcinoma	GDSC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.0833
p.G630D	ACH-001138	Lung Cancer	CCLE	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.0833
p.G630D	NCI-H2141	lung	COSMIC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.0833
p.G627S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627S	ACH-000937	Leukemia	CCLE	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627S	ACH-000937	Leukemia	CCLE	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G627S	PF-382	haematopoietic and lymphoid tissue	COSMIC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.G627S	PF-382	haematopoietic and lymphoid tissue	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1111
p.G624E	SIDM01546	Kidney Carcinoma	GDSC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624E	SIDM01546	Kidney Carcinoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1944
p.G624E	ACH-000234	Kidney Cancer	CCLE	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624E	ACH-000234	Kidney Cancer	CCLE	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC9A9

UniProt ID: Q8IVB4

Entrez ID: 285195

Protein name: Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC9A9 in