DegronMD - Q8IVB4(SLC9A9)

FUNCTION: May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. {ECO:0000269|PubMed:15522866}.

GO - Biological processes (BP): ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]

GO - Molecular function (MF): potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]

GO - Cellular component (CC): integral component of membrane [GO:0016021]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
GKENI	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	Sodium/hydrogen exchanger 9	617:621	More..
PQTPGKE	DEG_SCF_FBW7_2	FBXW7	Sodium/hydrogen exchanger 9	613:619	More..
PLTTT	DEG_SPOP_SBC_1	SPOP	Sodium/hydrogen exchanger 9	547:551	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T615K	DO229015	LICA	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation altering degron motif	0.8417
p.S612P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation blocking phosphorylation signal	0.75
p.T551K	DO229025	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7306
p.T550A	TCGA-CG-5721	STAD	TCGA	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7139
p.T550A	DO38192	STAD	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7139
p.E619K	TCGA-D3-A3C7	SKCM	TCGA	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7022
p.E619K	TCGA-D3-A3C7	SKCM	TCGA	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation altering degron motif	0.7022
p.E619K	DO47569	SKCM	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7022
p.E619K	DO47569	SKCM	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation altering degron motif	0.7022
p.S612P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation blocking phosphorylation signal	0.6389
p.G624V	TCGA-37-4141	LUSC	TCGA	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624V	DO26862	LUSC	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.S544Y	TCGA-AA-A010	COAD	TCGA	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.25
p.G624R	TCGA-DA-A95Z	SKCM	TCGA	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624R	DO219481	SKCM	ICGC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624E	SIDM01546	Kidney Carcinoma	GDSC	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.G624E	ACH-000234	Kidney Cancer	CCLE	GKENI	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.25
p.H543N	TCGA-B0-5096	KIRC	TCGA	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.H543N	DO19218	KIRC	ICGC	PLTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.Q609K	DO23522	LIRI	ICGC	PQTPGKE	DEG_SCF_FBW7_2	613:619	Mutation rewiring degron network	0.2222

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No resistance data available for this Degron.

Kaplan plot for SLC9A9 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC9A9

UniProt ID: Q8IVB4

Entrez ID: 285195

Protein name: Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for SLC9A9 in