DegronMD

Uniprot ID: Q8IVB4

Source protein: Sodium/hydrogen exchanger 9

Source gene: SLC9A9

Class: DEG_SCF_FBW7_2

Location: 613:619

E3 ligase: FBXW7

DEGRON score: 0.6851

ASA_SCORE: 94.8286

COIL: 0.9001

CONS_SCORE: 0.2536

DSS_SCORE: 0.6089

HELIX: 0.0539

FCONS_SCORE: 1.0238

RIG_SCORE: 0.6203

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G624V	TCGA-37-4141	LUSC	TCGA	PQTPGKE	DEG_SCF_FBW7_2	0.1944
p.G624V	DO26862	LUSC	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.1944
p.G627C	TCGA-38-4632	LUAD	TCGA	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627C	TCGA-86-6851	LUAD	TCGA	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627C	DO23858	LUAD	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627C	DO23798	LUAD	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627V	TCGA-44-2655	LUAD	TCGA	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627V	DO23557	LUAD	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627V	ACH-000929	Lung Cancer	CCLE	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627V	NCI-H2110	lung	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.E619K	TCGA-D3-A3C7	SKCM	TCGA	PQTPGKE	DEG_SCF_FBW7_2	0.7022
p.E619K	DO47569	SKCM	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.7022
p.G624R	TCGA-DA-A95Z	SKCM	TCGA	PQTPGKE	DEG_SCF_FBW7_2	0.1944
p.G624R	DO219481	SKCM	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.1944
p.T615K	DO229015	LICA	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.8417
p.L607M	DO229009	LICA	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.1667
p.Q609K	DO23522	LIRI	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.2222
p.Q609K	SIDM00761	Small Cell Lung Carcinoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	0.2222
p.Q609K	ACH-000752	Lung Cancer	CCLE	PQTPGKE	DEG_SCF_FBW7_2	0.2222
p.Q609K	NCI-H196	lung	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	0.2222
p.D608N	DO229462	SKCA	ICGC	PQTPGKE	DEG_SCF_FBW7_2	0.1944
p.A603E	SIDM00857	Melanoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	0.0556
p.A603E	SIDM00820	Kidney Carcinoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	0.0556
p.A603E	SIDM01193	Glioma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	0.0556
p.A603E	RCC-ER	kidney	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	0.0556
p.A603E	U-118-MG	central_nervous_system	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	0.0556
p.A603E	G-361	skin	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	0.0556
p.S612P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PQTPGKE	DEG_SCF_FBW7_2	0.75
p.G627S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627S	ACH-000937	Leukemia	CCLE	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G627S	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPGKE	DEG_SCF_FBW7_2	0.1111
p.G624E	SIDM01546	Kidney Carcinoma	GDSC	PQTPGKE	DEG_SCF_FBW7_2	0.1944
p.G624E	ACH-000234	Kidney Cancer	CCLE	PQTPGKE	DEG_SCF_FBW7_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTPGKE

Degron related mutations and impact score

Drug responses associated with SLC9A9 mutations

All proteins holding degron of PQTPGKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_SCF_FBW7_2	613:619	PQTPGKE	FBXW7	0.6851	More...