DegronMD

Uniprot ID: Q8IVB4

Source protein: Sodium/hydrogen exchanger 9

Source gene: SLC9A9

Class: DEG_APCC_KENBOX_2

Location: 617:621

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9769

ASA_SCORE: 86.9

COIL: 0.7874

CONS_SCORE: 0.2542

DSS_SCORE: 0.5918

HELIX: 0.113

FCONS_SCORE: 1.0167

RIG_SCORE: 0.6798

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G624V	TCGA-37-4141	LUSC	TCGA	GKENI	DEG_APCC_KENBOX_2	0.25
p.G624V	DO26862	LUSC	ICGC	GKENI	DEG_APCC_KENBOX_2	0.25
p.G627C	TCGA-38-4632	LUAD	TCGA	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627C	TCGA-86-6851	LUAD	TCGA	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627C	DO23858	LUAD	ICGC	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627C	DO23798	LUAD	ICGC	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627V	TCGA-44-2655	LUAD	TCGA	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627V	DO23557	LUAD	ICGC	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627V	ACH-000929	Lung Cancer	CCLE	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627V	NCI-H2110	lung	COSMIC	GKENI	DEG_APCC_KENBOX_2	0.1667
p.E619K	TCGA-D3-A3C7	SKCM	TCGA	GKENI	DEG_APCC_KENBOX_2	0.7022
p.E619K	DO47569	SKCM	ICGC	GKENI	DEG_APCC_KENBOX_2	0.7022
p.G624R	TCGA-DA-A95Z	SKCM	TCGA	GKENI	DEG_APCC_KENBOX_2	0.25
p.G624R	DO219481	SKCM	ICGC	GKENI	DEG_APCC_KENBOX_2	0.25
p.L607M	DO229009	LICA	ICGC	GKENI	DEG_APCC_KENBOX_2	0.0556
p.Q609K	DO23522	LIRI	ICGC	GKENI	DEG_APCC_KENBOX_2	0.1111
p.Q609K	SIDM00761	Small Cell Lung Carcinoma	GDSC	GKENI	DEG_APCC_KENBOX_2	0.1111
p.Q609K	ACH-000752	Lung Cancer	CCLE	GKENI	DEG_APCC_KENBOX_2	0.1111
p.Q609K	NCI-H196	lung	COSMIC	GKENI	DEG_APCC_KENBOX_2	0.1111
p.D608N	DO229462	SKCA	ICGC	GKENI	DEG_APCC_KENBOX_2	0.0833
p.S612P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	GKENI	DEG_APCC_KENBOX_2	0.6389
p.G630D	SIDM00699	Small Cell Lung Carcinoma	GDSC	GKENI	DEG_APCC_KENBOX_2	0.0833
p.G630D	ACH-001138	Lung Cancer	CCLE	GKENI	DEG_APCC_KENBOX_2	0.0833
p.G630D	NCI-H2141	lung	COSMIC	GKENI	DEG_APCC_KENBOX_2	0.0833
p.G627S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627S	ACH-000937	Leukemia	CCLE	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G627S	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	GKENI	DEG_APCC_KENBOX_2	0.1667
p.G624E	SIDM01546	Kidney Carcinoma	GDSC	GKENI	DEG_APCC_KENBOX_2	0.25
p.G624E	ACH-000234	Kidney Cancer	CCLE	GKENI	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_APCC_KENBOX_2	617:621	GKENI	APC,CDC20,FZR1	0.9769	More...
Q5VW32	BRO1 domain-containing protein BROX	DEG_APCC_KENBOX_2	131:135	GKENI	APC,CDC20,FZR1	0.8396	More...
Q8IXT2	Doublesex- and mab-3-related transcription factor C2	DEG_APCC_KENBOX_2	125:129	GKENI	APC,CDC20,FZR1	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKENI

Degron related mutations and impact score

Drug responses associated with SLC9A9 mutations

All proteins holding degron of GKENI