DegronMD - Q8IXT2(DMRTC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G116E	TCGA-EE-A29B	SKCM	TCGA	GKENI	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.0833
p.G116E	TCGA-QQ-A8VG	SARC	TCGA	GKENI	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.0833
p.G116E	DO220260	SARC	ICGC	GKENI	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.0833
p.G116E	DO47255	SKCM	ICGC	GKENI	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.0833
p.G116R	DO229177	LMS	ICGC	GKENI	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.0833
p.T117I	DO220891	MELA	ICGC	GKENI	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.1111
p.P123L	DO222702	MELA	ICGC	GKENI	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.2778
p.P123L	DO222702	MELA	ICGC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1667
p.P147S	DO229456	SKCA	ICGC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1944
p.P147S	DO229234	THCA	ICGC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1944
p.A130V	DO229253	THCA	ICGC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.6936
p.N150S	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1111
p.N150S	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons