DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IAPQPQTPHGAVLL
Uniprot ID:
Q8IXT2
Source protein:
Doublesex- and mab-3-related transcription factor C2
Source gene:
DMRTC2
Class:
DEG_ODPH_VHL_1
Location:
129:142
E3 ligase:
VHL
DEGRON score:
0.9112
ASA_SCORE:
89.2071
COIL:
0.9257
CONS_SCORE:
0.4786
DSS_SCORE:
0.7341
HELIX:
0.0291
FCONS_SCORE:
0.8903
RIG_SCORE:
0.6387
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P123L
DO222702
MELA
ICGC
IAPQPQTPHGAVLL
DEG_ODPH_VHL_1
0.1667
p.P147S
DO229456
SKCA
ICGC
IAPQPQTPHGAVLL
DEG_ODPH_VHL_1
0.1944
p.P147S
DO229234
THCA
ICGC
IAPQPQTPHGAVLL
DEG_ODPH_VHL_1
0.1944
p.A130V
DO229253
THCA
ICGC
IAPQPQTPHGAVLL
DEG_ODPH_VHL_1
0.6936
p.N150S
SIDM00412
B-Cell Non-Hodgkin's Lymphoma
GDSC
IAPQPQTPHGAVLL
DEG_ODPH_VHL_1
0.1111
p.N150S
WSU-NHL
haematopoietic_and_lymphoid_tissue
COSMIC
IAPQPQTPHGAVLL
DEG_ODPH_VHL_1
0.1111
Drug responses associated with DMRTC2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IAPQPQTPHGAVLL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IXT2
Doublesex- and mab-3-related transcription factor C2
DEG_ODPH_VHL_1
129:142
IAPQPQTPHGAVLL
VHL
0.9112
More...