DegronMD

Uniprot ID: Q8IXT2

Source protein: Doublesex- and mab-3-related transcription factor C2

Source gene: DMRTC2

Class: DEG_ODPH_VHL_1

Location: 129:142

E3 ligase: VHL

DEGRON score: 0.9112

ASA_SCORE: 89.2071

COIL: 0.9257

CONS_SCORE: 0.4786

DSS_SCORE: 0.7341

HELIX: 0.0291

FCONS_SCORE: 0.8903

RIG_SCORE: 0.6387

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A130V	DO229253	THCA	ICGC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	0.6936
p.P147S	DO229456	SKCA	ICGC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	0.1944
p.P147S	DO229234	THCA	ICGC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	0.1944
p.P123L	DO222702	MELA	ICGC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	0.1667
p.N150S	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	0.1111
p.N150S	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	IAPQPQTPHGAVLL	DEG_ODPH_VHL_1	0.1111

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXT2	Doublesex- and mab-3-related transcription factor C2	DEG_ODPH_VHL_1	129:142	IAPQPQTPHGAVLL	VHL	0.9112	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons