DegronMD

Uniprot ID: Q8IXT2

Source protein: Doublesex- and mab-3-related transcription factor C2

Source gene: DMRTC2

Class: DEG_APCC_KENBOX_2

Location: 125:129

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9948

ASA_SCORE: 99.72

COIL: 0.8708

CONS_SCORE: 0.6162

DSS_SCORE: 0.8476

HELIX: 0.0766

FCONS_SCORE: 1.2983

RIG_SCORE: 0.5924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G116E	TCGA-EE-A29B	SKCM	TCGA	GKENI	DEG_APCC_KENBOX_2	0.0833
p.G116E	TCGA-QQ-A8VG	SARC	TCGA	GKENI	DEG_APCC_KENBOX_2	0.0833
p.G116E	DO220260	SARC	ICGC	GKENI	DEG_APCC_KENBOX_2	0.0833
p.G116E	DO47255	SKCM	ICGC	GKENI	DEG_APCC_KENBOX_2	0.0833
p.G116R	DO229177	LMS	ICGC	GKENI	DEG_APCC_KENBOX_2	0.0833
p.T117I	DO220891	MELA	ICGC	GKENI	DEG_APCC_KENBOX_2	0.1111
p.P123L	DO222702	MELA	ICGC	GKENI	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_APCC_KENBOX_2	617:621	GKENI	APC,CDC20,FZR1	0.9769	More...
Q5VW32	BRO1 domain-containing protein BROX	DEG_APCC_KENBOX_2	131:135	GKENI	APC,CDC20,FZR1	0.8396	More...
Q8IXT2	Doublesex- and mab-3-related transcription factor C2	DEG_APCC_KENBOX_2	125:129	GKENI	APC,CDC20,FZR1	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons