DegronMD - Q5VW32(BROX)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L36F	TCGA-5L-AAT1	BRCA	TCGA	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1111
p.L36F	DO219594	BRCA	ICGC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1111
p.R42Q	TCGA-77-A5G7	LUSC	TCGA	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.2778
p.R42Q	TCGA-AX-A2HA	UCEC	TCGA	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.2778
p.R42Q	TCGA-ZF-A9R7	BLCA	TCGA	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.2778
p.R42Q	DO219064	BLCA	ICGC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.2778
p.R42Q	DO50098	LUSC	ICGC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.2778
p.R42Q	DO42504	UCEC	ICGC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.2778
p.E137Q	TCGA-CV-A45X	HNSC	TCGA	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation rewiring degron network	0.2778
p.E137Q	DO52062	HNSC	ICGC	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation rewiring degron network	0.2778
p.E55G	TCGA-D3-A8GQ	SKCM	TCGA	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1667
p.E55G	DO51246	SKCM	ICGC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1667
p.D138G	TCGA-DF-A2KZ	UCEC	TCGA	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation rewiring degron network	0.25
p.D138G	DO52409	UCEC	ICGC	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation rewiring degron network	0.25
p.W121L	TCGA-G7-6795	KIRP	TCGA	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation rewiring degron network	0.0556
p.W121L	DO20851	KIRP	ICGC	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation rewiring degron network	0.0556
p.A41V	DO228583	GACA	ICGC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.25
p.H124P	DO233641	GACA	ICGC	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation substituting flanking lysine	0.25
p.A41S	DO229035	LICA	ICGC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.25
p.R37M	DO229037	LICA	ICGC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1389
p.A126S	DO229045	LICA	ICGC	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation rewiring degron network	0.1944
p.K58R	SIDM00832	Colorectal Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation substituting flanking lysine	0.1944
p.K58R	ACH-000680	Colon/Colorectal Cancer	CCLE	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation substituting flanking lysine	0.1944
p.K58R	SW948	large intestine	COSMIC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation substituting flanking lysine	0.1944
p.P54T	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1944
p.P54T	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1944
p.P54T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1944
p.P54T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1944
p.R40G	ACH-002048	Sarcoma	CCLE	LELFTD	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.2222
p.F122L	GOTO	autonomic ganglia	COSMIC	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation rewiring degron network	0.0833
p.R141G	EW-7	bone	COSMIC	GKENI	DEG_APCC_KENBOX_2	131:135	Mutation blocking ubiquitination signal	0.6111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BROX

UniProt ID: Q5VW32

Entrez ID: 148362

Protein name: BRO1 domain-containing protein BROX (BRO1 domain- and CAAX motif-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BROX in