DegronMD

Uniprot ID: Q5VW32

Source protein: BRO1 domain-containing protein BROX

Source gene: BROX

Class: LIG_APCC_ABBA_1

Location: 44:49

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6249

ASA_SCORE: 55.3667

COIL: 0.2855

CONS_SCORE: 0.562

DSS_SCORE: 0.1729

HELIX: 0.7053

FCONS_SCORE: 1.2166

RIG_SCORE: 0.8865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L36F	TCGA-5L-AAT1	BRCA	TCGA	LELFTD	LIG_APCC_ABBA_1	0.1111
p.L36F	DO219594	BRCA	ICGC	LELFTD	LIG_APCC_ABBA_1	0.1111
p.R42Q	TCGA-77-A5G7	LUSC	TCGA	LELFTD	LIG_APCC_ABBA_1	0.2778
p.R42Q	TCGA-AX-A2HA	UCEC	TCGA	LELFTD	LIG_APCC_ABBA_1	0.2778
p.R42Q	TCGA-ZF-A9R7	BLCA	TCGA	LELFTD	LIG_APCC_ABBA_1	0.2778
p.R42Q	DO219064	BLCA	ICGC	LELFTD	LIG_APCC_ABBA_1	0.2778
p.R42Q	DO50098	LUSC	ICGC	LELFTD	LIG_APCC_ABBA_1	0.2778
p.R42Q	DO42504	UCEC	ICGC	LELFTD	LIG_APCC_ABBA_1	0.2778
p.E55G	TCGA-D3-A8GQ	SKCM	TCGA	LELFTD	LIG_APCC_ABBA_1	0.1667
p.E55G	DO51246	SKCM	ICGC	LELFTD	LIG_APCC_ABBA_1	0.1667
p.A41V	DO228583	GACA	ICGC	LELFTD	LIG_APCC_ABBA_1	0.25
p.A41S	DO229035	LICA	ICGC	LELFTD	LIG_APCC_ABBA_1	0.25
p.R37M	DO229037	LICA	ICGC	LELFTD	LIG_APCC_ABBA_1	0.1389
p.K58R	SIDM00832	Colorectal Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	0.1944
p.K58R	ACH-000680	Colon/Colorectal Cancer	CCLE	LELFTD	LIG_APCC_ABBA_1	0.1944
p.K58R	SW948	large_intestine	COSMIC	LELFTD	LIG_APCC_ABBA_1	0.1944
p.P54T	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	0.1944
p.P54T	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	0.1944
p.P54T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	0.1944
p.P54T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	LELFTD	LIG_APCC_ABBA_1	0.1944
p.R40G	ACH-002048	Sarcoma	CCLE	LELFTD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VW32	BRO1 domain-containing protein BROX	LIG_APCC_ABBA_1	44:49	LELFTD	APC,CDC20,FZR1	0.6249	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons