DegronMD

Uniprot ID: Q5VW32

Source protein: BRO1 domain-containing protein BROX

Source gene: BROX

Class: DEG_APCC_KENBOX_2

Location: 131:135

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8396

ASA_SCORE: 83.18

COIL: 0.9466

CONS_SCORE: 0.4415

DSS_SCORE: 0.2534

HELIX: 0.0352

FCONS_SCORE: 0.7853

RIG_SCORE: 0.7666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E137Q	TCGA-CV-A45X	HNSC	TCGA	GKENI	DEG_APCC_KENBOX_2	0.2778
p.E137Q	DO52062	HNSC	ICGC	GKENI	DEG_APCC_KENBOX_2	0.2778
p.D138G	TCGA-DF-A2KZ	UCEC	TCGA	GKENI	DEG_APCC_KENBOX_2	0.25
p.D138G	DO52409	UCEC	ICGC	GKENI	DEG_APCC_KENBOX_2	0.25
p.W121L	TCGA-G7-6795	KIRP	TCGA	GKENI	DEG_APCC_KENBOX_2	0.0556
p.W121L	DO20851	KIRP	ICGC	GKENI	DEG_APCC_KENBOX_2	0.0556
p.H124P	DO233641	GACA	ICGC	GKENI	DEG_APCC_KENBOX_2	0.25
p.A126S	DO229045	LICA	ICGC	GKENI	DEG_APCC_KENBOX_2	0.1944
p.F122L	GOTO	autonomic_ganglia	COSMIC	GKENI	DEG_APCC_KENBOX_2	0.0833
p.R141G	EW-7	bone	COSMIC	GKENI	DEG_APCC_KENBOX_2	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_APCC_KENBOX_2	617:621	GKENI	APC,CDC20,FZR1	0.9769	More...
Q5VW32	BRO1 domain-containing protein BROX	DEG_APCC_KENBOX_2	131:135	GKENI	APC,CDC20,FZR1	0.8396	More...
Q8IXT2	Doublesex- and mab-3-related transcription factor C2	DEG_APCC_KENBOX_2	125:129	GKENI	APC,CDC20,FZR1	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons