DegronMD - Q14684(RRP1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A450T	TCGA-2W-A8YY	CESC	TCGA	ATSST	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7139
p.A450T	DO223732	CESC	ICGC	ATSST	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7139
p.P743L	TCGA-62-A46O	LUAD	TCGA	PLTTT	DEG_SPOP_SBC_1	743:747	Mutation altering degron motif	0.7582
p.P743L	DO26240	LUAD	ICGC	PLTTT	DEG_SPOP_SBC_1	743:747	Mutation altering degron motif	0.7582
p.G447D	TCGA-AG-3598	READ	TCGA	ATSST	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.25
p.G447D	DO36534	READ	ICGC	ATSST	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.25
p.A448T	TCGA-B0-5098	KIRC	TCGA	ATSST	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2778
p.A448T	DO18938	KIRC	ICGC	ATSST	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2778
p.G687W	TCGA-BF-A1PZ	SKCM	TCGA	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation rewiring degron network	0.1667
p.G687W	DO229008	LICA	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation rewiring degron network	0.1667
p.G687W	DO50279	SKCM	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation rewiring degron network	0.1667
p.P463H	TCGA-DF-A2KU	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.0833
p.P463H	DO223286	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.0833
p.P667H	TCGA-DF-A2KU	UCEC	TCGA	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation rewiring degron network	0.1389
p.P667H	TCGA-DF-A2KU	UCEC	TCGA	AKSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.2222
p.P667H	DO223286	UCEC	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation rewiring degron network	0.1389
p.P667H	DO223286	UCEC	ICGC	AKSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.2222
p.V672I	TCGA-EA-A3HU	CESC	TCGA	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation rewiring degron network	0.2778
p.V672I	TCGA-EA-A3HU	CESC	TCGA	AKSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0833
p.V672I	DO6320	CESC	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation rewiring degron network	0.2778
p.V672I	DO6320	CESC	ICGC	AKSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0833
p.E718K	DO48390	BLCA	ICGC	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation rewiring degron network	0.1389
p.A740S	DO229029	LICA	ICGC	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation rewiring degron network	0.1111
p.A740S	DO229029	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.25
p.G455W	DO229025	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.3056
p.G669V	DO229036	LICA	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation rewiring degron network	0.1944
p.G669V	DO229036	LICA	ICGC	AKSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1667
p.K720N	DO229037	LICA	ICGC	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation substituting flanking lysine	0.3056
p.S680I	DO229008	LICA	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation altering degron motif	0.7341
p.P748L	DO229177	LMS	ICGC	PLTTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.3056
p.T451M	DO232224	PBCA	ICGC	ATSST	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7423
p.T665N	DO229264	THCA	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	674:681	Mutation blocking phosphorylation signal	0.5278
p.T665N	DO229264	THCA	ICGC	AKSST	DEG_SPOP_SBC_1	659:663	Mutation blocking phosphorylation signal	0.7222
p.G724E	SIDM01096	Colorectal Carcinoma	GDSC	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation rewiring degron network	0.3056
p.G724E	ACH-000400	Colon/Colorectal Cancer	CCLE	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation rewiring degron network	0.3056
p.G724E	SK-CO-1	large intestine	COSMIC	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation rewiring degron network	0.3056
p.G724W	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation rewiring degron network	0.3056
p.G724W	ACH-000914	Lymphoma	CCLE	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation rewiring degron network	0.3056
p.G724W	HT	haematopoietic and lymphoid tissue	COSMIC	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation rewiring degron network	0.3056
p.L726M	SIDM00562	Breast Carcinoma	GDSC	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation altering degron motif	0.5999
p.L726M	ACH-002163	Breast Cancer	CCLE	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation altering degron motif	0.5999
p.L726M	MRK-nu-1	breast	COSMIC	VLKTPTSS	DEG_SCF_FBW7_1	725:732	Mutation altering degron motif	0.5999
p.L654M	SIDM01105	Melanoma	GDSC	AKSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1944
p.L654M	ACH-000423	Skin Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1944
p.L654M	SK-MEL-3	skin	COSMIC	AKSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1944
p.R442H	SIDM01511	Gastric Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1111
p.R442H	ACH-000746	Gastric Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1111

Kaplan plot for RRP1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RRP1B

UniProt ID: Q14684

Entrez ID: 23076

Protein name: Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RRP1B in