DegronMD

Uniprot ID: Q14684

Source protein: Ribosomal RNA processing protein 1 homolog B

Source gene: RRP1B

Class: DEG_SCF_FBW7_1

Location: 725:732

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 76.0625

COIL: 0.8993

CONS_SCORE: 0.4818

DSS_SCORE: 0.6401

HELIX: 0.0265

FCONS_SCORE: 1.0263

RIG_SCORE: 0.624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E718K	DO48390	BLCA	ICGC	VLKTPTSS	DEG_SCF_FBW7_1	0.1389
p.A740S	DO229029	LICA	ICGC	VLKTPTSS	DEG_SCF_FBW7_1	0.1111
p.K720N	DO229037	LICA	ICGC	VLKTPTSS	DEG_SCF_FBW7_1	0.3056
p.G724E	SIDM01096	Colorectal Carcinoma	GDSC	VLKTPTSS	DEG_SCF_FBW7_1	0.3056
p.G724E	ACH-000400	Colon/Colorectal Cancer	CCLE	VLKTPTSS	DEG_SCF_FBW7_1	0.3056
p.G724E	SK-CO-1	large_intestine	COSMIC	VLKTPTSS	DEG_SCF_FBW7_1	0.3056
p.G724W	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLKTPTSS	DEG_SCF_FBW7_1	0.3056
p.G724W	ACH-000914	Lymphoma	CCLE	VLKTPTSS	DEG_SCF_FBW7_1	0.3056
p.G724W	HT	haematopoietic_and_lymphoid_tissue	COSMIC	VLKTPTSS	DEG_SCF_FBW7_1	0.3056
p.L726M	SIDM00562	Breast Carcinoma	GDSC	VLKTPTSS	DEG_SCF_FBW7_1	0.5999
p.L726M	ACH-002163	Breast Cancer	CCLE	VLKTPTSS	DEG_SCF_FBW7_1	0.5999
p.L726M	MRK-nu-1	breast	COSMIC	VLKTPTSS	DEG_SCF_FBW7_1	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SCF_FBW7_1	725:732	VLKTPTSS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons