DegronMD

Uniprot ID: Q14684

Source protein: Ribosomal RNA processing protein 1 homolog B

Source gene: RRP1B

Class: DEG_SPOP_SBC_1

Location: 659:663

E3 ligase: SPOP

DEGRON score: 0.9985

ASA_SCORE: 100.14

COIL: 0.9292

CONS_SCORE: 0.1063

DSS_SCORE: 0.5495

HELIX: 0.0326

FCONS_SCORE: 0.8824

RIG_SCORE: 0.6487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P667H	TCGA-DF-A2KU	UCEC	TCGA	AKSST	DEG_SPOP_SBC_1	0.2222
p.P667H	DO223286	UCEC	ICGC	AKSST	DEG_SPOP_SBC_1	0.2222
p.V672I	TCGA-EA-A3HU	CESC	TCGA	AKSST	DEG_SPOP_SBC_1	0.0833
p.V672I	DO6320	CESC	ICGC	AKSST	DEG_SPOP_SBC_1	0.0833
p.G669V	DO229036	LICA	ICGC	AKSST	DEG_SPOP_SBC_1	0.1667
p.T665N	DO229264	THCA	ICGC	AKSST	DEG_SPOP_SBC_1	0.7222
p.L654M	SIDM01105	Melanoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.1944
p.L654M	ACH-000423	Skin Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	0.1944
p.L654M	SK-MEL-3	skin	COSMIC	AKSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	747:751	AKSST	SPOP	0.7998	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	659:663	AKSST	SPOP	0.9985	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	989:993	AKSST	SPOP	0.7562	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	372:376	AKSST	SPOP	0.8922	More...
Q5SZJ8	BEN domain-containing protein 6	DEG_SPOP_SBC_1	214:218	AKSST	SPOP	0.9533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons