DegronMD

Uniprot ID: Q5SZJ8

Source protein: BEN domain-containing protein 6

Source gene: BEND6

Class: DEG_SPOP_SBC_1

Location: 214:218

E3 ligase: SPOP

DEGRON score: 0.9533

ASA_SCORE: 74.42

COIL: 0.7684

CONS_SCORE: 0.9562

DSS_SCORE: 0.4984

HELIX: 0.0724

FCONS_SCORE: 1.0524

RIG_SCORE: 0.659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A223D	TCGA-A5-A0G1	UCEC	TCGA	AKSST	DEG_SPOP_SBC_1	0.1944
p.A223D	DO42472	UCEC	ICGC	AKSST	DEG_SPOP_SBC_1	0.1944
p.E204K	TCGA-EE-A2MM	SKCM	TCGA	AKSST	DEG_SPOP_SBC_1	0.0556
p.E204K	DO222678	MELA	ICGC	AKSST	DEG_SPOP_SBC_1	0.0556
p.E204K	DO37770	SKCM	ICGC	AKSST	DEG_SPOP_SBC_1	0.0556
p.S216F	TCGA-FS-A1ZC	SKCM	TCGA	AKSST	DEG_SPOP_SBC_1	0.7982
p.S216F	DO37487	SKCM	ICGC	AKSST	DEG_SPOP_SBC_1	0.7982
p.A214T	TCGA-G9-6364	PRAD	TCGA	AKSST	DEG_SPOP_SBC_1	0.7139
p.A214T	DO36240	PRAD	ICGC	AKSST	DEG_SPOP_SBC_1	0.7139
p.A207T	DO222404	BTCA	ICGC	AKSST	DEG_SPOP_SBC_1	0.1389
p.A214S	DO229019	LICA	ICGC	AKSST	DEG_SPOP_SBC_1	0.7588
p.H209N	DO231174	LUSC	ICGC	AKSST	DEG_SPOP_SBC_1	0.1944
p.S217F	DO222662	MELA	ICGC	AKSST	DEG_SPOP_SBC_1	0.7982
p.A207V	DO228138	PBCA	ICGC	AKSST	DEG_SPOP_SBC_1	0.1389
p.A207V	SIDM01960	Colorectal Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.1389
p.P226S	SIDM00683	Prostate Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.1111
p.P226S	LNCaP-Clone-FGC	prostate	COSMIC	AKSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	747:751	AKSST	SPOP	0.7998	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	659:663	AKSST	SPOP	0.9985	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	989:993	AKSST	SPOP	0.7562	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	372:376	AKSST	SPOP	0.8922	More...
Q5SZJ8	BEN domain-containing protein 6	DEG_SPOP_SBC_1	214:218	AKSST	SPOP	0.9533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons