DegronMD

Uniprot ID: Q9Y2R2

Source protein: Tyrosine-protein phosphatase non-receptor type 22

Source gene: PTPN22

Class: DEG_SPOP_SBC_1

Location: 372:376

E3 ligase: SPOP

DEGRON score: 0.8922

ASA_SCORE: 80.3

COIL: 0.8248

CONS_SCORE: 0.2789

DSS_SCORE: 0.1957

HELIX: 0.0674

FCONS_SCORE: 0.9924

RIG_SCORE: 0.7168

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L381P	TCGA-21-5783	LUSC	TCGA	AKSST	DEG_SPOP_SBC_1	0.1944
p.L381P	DO27437	LUSC	ICGC	AKSST	DEG_SPOP_SBC_1	0.1944
p.L369V	TCGA-2W-A8YY	CESC	TCGA	AKSST	DEG_SPOP_SBC_1	0.25
p.L369V	DO223732	CESC	ICGC	AKSST	DEG_SPOP_SBC_1	0.25
p.L381V	TCGA-AR-A0TX	BRCA	TCGA	AKSST	DEG_SPOP_SBC_1	0.1944
p.L381V	DO1663	BRCA	ICGC	AKSST	DEG_SPOP_SBC_1	0.1944
p.E382K	TCGA-DK-A6AW	BLCA	TCGA	AKSST	DEG_SPOP_SBC_1	0.1667
p.E382K	DO48566	BLCA	ICGC	AKSST	DEG_SPOP_SBC_1	0.1667
p.E382K	SIDM00185	Melanoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.1667
p.E382K	ACH-002152	Skin Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	0.1667
p.E382K	LB2518-MEL	skin	COSMIC	AKSST	DEG_SPOP_SBC_1	0.1667
p.P371T	TCGA-EE-A29E	SKCM	TCGA	AKSST	DEG_SPOP_SBC_1	0.3056
p.P371T	DO37831	SKCM	ICGC	AKSST	DEG_SPOP_SBC_1	0.3056
p.S374L	DO222875	MELA	ICGC	AKSST	DEG_SPOP_SBC_1	0.7667
p.H370N	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.H370N	SIDM00072	Non-Cancerous	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.H370N	SIDM01164	Glioma	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.H370N	SIDM00779	Colorectal Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.H370N	SIDM00710	Small Cell Lung Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.H370N	SIDM01050	Biliary Tract Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.H370N	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.H370N	SIDM01193	Glioma	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.H370N	SIDM01759	Hodgkin's Lymphoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.H370N	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.2778
p.S377Y	SIDM01611	Endometrial Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.3056
p.S377Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	0.3056
p.S386I	SIDM01782	Oral Cavity Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.0556
p.S386I	ACH-000723	Head and Neck Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	0.0556
p.T376I	ACH-001377	Pancreatic Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	0.7078
p.T376I	ACH-001380	Pancreatic Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	0.7078
p.Y376C	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	AKSST	DEG_SPOP_SBC_1	0.7087
p.Y376C	HCC-78	lung	COSMIC	AKSST	DEG_SPOP_SBC_1	0.7087
p.A379T	COR-L88	lung	COSMIC	AKSST	DEG_SPOP_SBC_1	0.25
p.P375S	HT-115	large_intestine	COSMIC	AKSST	DEG_SPOP_SBC_1	0.6752
p.S378C	CAL-85-1	breast	COSMIC	AKSST	DEG_SPOP_SBC_1	0.2778
p.S366Y	LNCaP-Clone-FGC	prostate	COSMIC	AKSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	747:751	AKSST	SPOP	0.7998	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	659:663	AKSST	SPOP	0.9985	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	989:993	AKSST	SPOP	0.7562	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	372:376	AKSST	SPOP	0.8922	More...
Q5SZJ8	BEN domain-containing protein 6	DEG_SPOP_SBC_1	214:218	AKSST	SPOP	0.9533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKSST

Degron related mutations and impact score

Drug responses associated with PTPN22 mutations

All proteins holding degron of AKSST