DegronMD

Uniprot ID: O94885

Source protein: SAM and SH3 domain-containing protein 1

Source gene: SASH1

Class: DEG_SPOP_SBC_1

Location: 747:751

E3 ligase: SPOP

DEGRON score: 0.7998

ASA_SCORE: 91.56

COIL: 0.8128

CONS_SCORE: 0.2328

DSS_SCORE: 0.5137

HELIX: 0.1528

FCONS_SCORE: 0.8718

RIG_SCORE: 0.6351

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R740L	TCGA-09-2044	OV	TCGA	AKSST	DEG_SPOP_SBC_1	0.1389
p.R740L	DO28923	OV	ICGC	AKSST	DEG_SPOP_SBC_1	0.1389
p.R740W	TCGA-AZ-4315	COAD	TCGA	AKSST	DEG_SPOP_SBC_1	0.1389
p.R740W	DO8842	COAD	ICGC	AKSST	DEG_SPOP_SBC_1	0.1389
p.R740W	SIDM00680	Colorectal Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.1389
p.R740W	SIDM00318	Kidney Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	0.1389
p.R740W	ACH-000484	Kidney Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	0.1389
p.R740W	ACH-000957	Colon/Colorectal Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	0.1389
p.R740W	LS-180	large_intestine	COSMIC	AKSST	DEG_SPOP_SBC_1	0.1389
p.R740W	VMRC-RCW	kidney	COSMIC	AKSST	DEG_SPOP_SBC_1	0.1389
p.E752D	TCGA-EA-A3HU	CESC	TCGA	AKSST	DEG_SPOP_SBC_1	0.3056
p.E752D	DO6320	CESC	ICGC	AKSST	DEG_SPOP_SBC_1	0.3056
p.S757C	DO222452	ESCA	ICGC	AKSST	DEG_SPOP_SBC_1	0.1667
p.S754N	DO222843	MELA	ICGC	AKSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	747:751	AKSST	SPOP	0.7998	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	659:663	AKSST	SPOP	0.9985	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	989:993	AKSST	SPOP	0.7562	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	372:376	AKSST	SPOP	0.8922	More...
Q5SZJ8	BEN domain-containing protein 6	DEG_SPOP_SBC_1	214:218	AKSST	SPOP	0.9533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons