DegronMD

Uniprot ID: Q14684

Source protein: Ribosomal RNA processing protein 1 homolog B

Source gene: RRP1B

Class: DEG_SCF_FBW7_1

Location: 674:681

E3 ligase: FBXW7

DEGRON score: 0.9609

ASA_SCORE: 93.975

COIL: 0.8905

CONS_SCORE: 0.4699

DSS_SCORE: 0.5817

HELIX: 0.0419

FCONS_SCORE: 1.5736

RIG_SCORE: 0.6546

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G687W	TCGA-BF-A1PZ	SKCM	TCGA	LNKTPSSS	DEG_SCF_FBW7_1	0.1667
p.G687W	DO229008	LICA	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	0.1667
p.G687W	DO50279	SKCM	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	0.1667
p.P667H	TCGA-DF-A2KU	UCEC	TCGA	LNKTPSSS	DEG_SCF_FBW7_1	0.1389
p.P667H	DO223286	UCEC	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	0.1389
p.V672I	TCGA-EA-A3HU	CESC	TCGA	LNKTPSSS	DEG_SCF_FBW7_1	0.2778
p.V672I	DO6320	CESC	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	0.2778
p.G669V	DO229036	LICA	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	0.1944
p.S680I	DO229008	LICA	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	0.7341
p.T665N	DO229264	THCA	ICGC	LNKTPSSS	DEG_SCF_FBW7_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SCF_FBW7_1	674:681	LNKTPSSS	FBXW7	0.9609	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons