DegronMD

Uniprot ID: Q14684

Source protein: Ribosomal RNA processing protein 1 homolog B

Source gene: RRP1B

Class: DEG_SPOP_SBC_1

Location: 743:747

E3 ligase: SPOP

DEGRON score: 0.9993

ASA_SCORE: 101.8

COIL: 0.9614

CONS_SCORE: 0.4538

DSS_SCORE: 0.688

HELIX: 0.0192

FCONS_SCORE: 1.1766

RIG_SCORE: 0.7044

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P743L	TCGA-62-A46O	LUAD	TCGA	PLTTT	DEG_SPOP_SBC_1	0.7582
p.P743L	DO26240	LUAD	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7582
p.A740S	DO229029	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.25
p.P748L	DO229177	LMS	ICGC	PLTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95206	Protocadherin-8	DEG_SPOP_SBC_1	699:703	PLTTT	SPOP	0.9524	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	165:169	PLTTT	SPOP	0.9751	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1755:1759	PLTTT	SPOP	0.8841	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	743:747	PLTTT	SPOP	0.9993	More...
Q53H47	Histone-lysine N-methyltransferase SETMAR	DEG_SPOP_SBC_1	425:429	PLTTT	SPOP	0.5678	More...
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_SPOP_SBC_1	547:551	PLTTT	SPOP	0.5232	More...
Q8ND30	Liprin-beta-2	DEG_SPOP_SBC_1	804:808	PLTTT	SPOP	0.9988	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8776:8780	PLTTT	SPOP	0.9519	More...
Q9HCM2	Plexin-A4	DEG_SPOP_SBC_1	107:111	PLTTT	SPOP	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons