DegronMD

Uniprot ID: Q9HCM2

Source protein: Plexin-A4

Source gene: PLXNA4

Class: DEG_SPOP_SBC_1

Location: 107:111

E3 ligase: SPOP

DEGRON score: 0.514

ASA_SCORE: 76.96

COIL: 0.7658

CONS_SCORE: 0.4659

DSS_SCORE: 0.274

HELIX: 0.0222

FCONS_SCORE: 0.9764

RIG_SCORE: 0.8046

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L119V	TCGA-44-5644	LUAD	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1111
p.L119V	DO25153	LUAD	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1111
p.R99S	TCGA-66-2769	LUSC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1111
p.R99S	DO26522	LUSC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1111
p.R99L	TCGA-86-8358	LUAD	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1111
p.R99L	DO25471	LUAD	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1111
p.V101I	TCGA-AX-A06F	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1667
p.V101I	DO229016	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1667
p.V101I	DO41752	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1667
p.N112S	TCGA-B5-A0JY	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.3056
p.N112S	DO43041	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.3056
p.N115D	TCGA-DI-A1BU	UCEC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.2222
p.N115D	DO42023	UCEC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.L119I	TCGA-EE-A2MJ	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1111
p.L119I	DO38099	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1111
p.K116N	TCGA-IB-7651	PAAD	TCGA	PLTTT	DEG_SPOP_SBC_1	0.3056
p.K116N	DO46657	PAAD	ICGC	PLTTT	DEG_SPOP_SBC_1	0.3056
p.P97S	TCGA-YG-AA3N	SKCM	TCGA	PLTTT	DEG_SPOP_SBC_1	0.0556
p.P97S	DO51298	SKCM	ICGC	PLTTT	DEG_SPOP_SBC_1	0.0556
p.T111N	DO227872	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7055
p.T111N	DO52491	COCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.7055
p.V114I	DO233764	GACA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.25
p.R99H	DO228816	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1111
p.R99H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PLTTT	DEG_SPOP_SBC_1	0.1111
p.R99H	ACH-002222	Leukemia	CCLE	PLTTT	DEG_SPOP_SBC_1	0.1111
p.R99H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.1111
p.N113S	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PLTTT	DEG_SPOP_SBC_1	0.2778
p.N113S	ACH-000953	Leukemia	CCLE	PLTTT	DEG_SPOP_SBC_1	0.2778
p.N113S	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PLTTT	DEG_SPOP_SBC_1	0.2778
p.Q102K	SIDM01612	Endometrial Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.1944
p.Q102K	ACH-000946	Endometrial/Uterine Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95206	Protocadherin-8	DEG_SPOP_SBC_1	699:703	PLTTT	SPOP	0.9524	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	165:169	PLTTT	SPOP	0.9751	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1755:1759	PLTTT	SPOP	0.8841	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	743:747	PLTTT	SPOP	0.9993	More...
Q53H47	Histone-lysine N-methyltransferase SETMAR	DEG_SPOP_SBC_1	425:429	PLTTT	SPOP	0.5678	More...
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_SPOP_SBC_1	547:551	PLTTT	SPOP	0.5232	More...
Q8ND30	Liprin-beta-2	DEG_SPOP_SBC_1	804:808	PLTTT	SPOP	0.9988	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8776:8780	PLTTT	SPOP	0.9519	More...
Q9HCM2	Plexin-A4	DEG_SPOP_SBC_1	107:111	PLTTT	SPOP	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTTT

Degron related mutations and impact score

Drug responses associated with PLXNA4 mutations

All proteins holding degron of PLTTT