DegronMD - O95206(PCDH8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R697H	TCGA-56-7822	LUSC	TCGA	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2778
p.R697H	DO26638	LUSC	ICGC	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2778
p.D926N	TCGA-AP-A1DO	UCEC	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.2222
p.D926N	TCGA-B5-A3FA	UCEC	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.2222
p.D928N	TCGA-DF-A2KU	UCEC	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1667
p.G920R	TCGA-EE-A29E	SKCM	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation altering degron motif	0.6457
p.A704T	TCGA-IB-7651	PAAD	TCGA	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.3056
p.A704T	DO46657	PAAD	ICGC	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.3056
p.D694A	DO48437	BLCA	ICGC	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1944
p.V920I	DO222976	BTCA	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation altering degron motif	0.7076
p.A909V	DO8490	COAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1389
p.H926L	DO234437	ESAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.2222
p.E922Q	DO15286	HNSC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation altering degron motif	0.6744
p.T932K	DO229026	LICA	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.0556
p.L917M	DO229032	LICA	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation altering degron motif	0.711
p.Q918K	DO23618	LUAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation altering degron motif	0.6944
p.Q908L	DO24850	LUAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1111
p.Q910K	DO37831	SKCM	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1667
p.Y907C	DO38380	STAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.0833
p.Y907C	DO43306	UCEC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.0833
p.Y906C	DO42023	UCEC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.0556
p.P912S	DO43186	UCEC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.2222
p.A909T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1389
p.A909T	ACH-002272	Lymphoma	CCLE	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1389
p.A909T	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1389
p.R697G	SIDM00633	Breast Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2778
p.G695S	SIDM00529	Breast Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2222
p.S927N	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1944
p.S927N	ACH-002059	Leukemia	CCLE	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1944
p.S927N	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.1944
p.S932C	SIDM00907	Burkitt's Lymphoma	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation rewiring degron network	0.0556
p.D921G	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation altering degron motif	0.6087
p.D921G	ACH-001498	Lymphoma	CCLE	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation altering degron motif	0.6087
p.D921G	Farage	haematopoietic and lymphoid tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation altering degron motif	0.6087
p.V709M	SIDM01779	Gastric Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1667
p.V709M	ACH-000761	Gastric Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1667
p.T703N	ACH-000248	Breast Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation altering degron motif	0.7055
p.S707T	ACH-000617	Ovarian Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2222
p.L911P	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	916:922	Mutation substituting flanking lysine	0.3056

Kaplan plot for PCDH8 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDH8

UniProt ID: O95206

Entrez ID: 5100

Protein name: Protocadherin-8 (Arcadlin)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PCDH8 in