DegronMD

Uniprot ID: O95206

Source protein: Protocadherin-8

Source gene: PCDH8

Class: DEG_SCF_TRCP1_1

Location: 916:922

E3 ligase: BTRC

DEGRON score: 0.9138

ASA_SCORE: 52.0857

COIL: 0.8277

CONS_SCORE: 0.5311

DSS_SCORE: 0.5605

HELIX: 0.0986

FCONS_SCORE: 1.0209

RIG_SCORE: 0.5771

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D926N	TCGA-AP-A1DO	UCEC	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	0.2222
p.D926N	TCGA-B5-A3FA	UCEC	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	0.2222
p.D928N	TCGA-DF-A2KU	UCEC	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	0.1667
p.G920R	TCGA-EE-A29E	SKCM	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	0.6457
p.V920I	DO222976	BTCA	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.7076
p.A909V	DO8490	COAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.1389
p.H926L	DO234437	ESAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.2222
p.E922Q	DO15286	HNSC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.6744
p.T932K	DO229026	LICA	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.0556
p.L917M	DO229032	LICA	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.711
p.Q918K	DO23618	LUAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.6944
p.Q908L	DO24850	LUAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.1111
p.Q910K	DO37831	SKCM	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.1667
p.Y907C	DO38380	STAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.0833
p.Y907C	DO43306	UCEC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.0833
p.Y906C	DO42023	UCEC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.0556
p.P912S	DO43186	UCEC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.2222
p.A909T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	0.1389
p.A909T	ACH-002272	Lymphoma	CCLE	DSGKGDS	DEG_SCF_TRCP1_1	0.1389
p.A909T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	0.1389
p.S927N	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	0.1944
p.S927N	ACH-002059	Leukemia	CCLE	DSGKGDS	DEG_SCF_TRCP1_1	0.1944
p.S927N	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	0.1944
p.S932C	SIDM00907	Burkitt's Lymphoma	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	0.0556
p.D921G	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	0.6087
p.D921G	ACH-001498	Lymphoma	CCLE	DSGKGDS	DEG_SCF_TRCP1_1	0.6087
p.D921G	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	0.6087
p.L911P	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGKGDS

Degron related mutations and impact score

Drug responses associated with PCDH8 mutations

All proteins holding degron of DSGKGDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95206	Protocadherin-8	DEG_SCF_TRCP1_1	916:922	DSGKGDS	BTRC	0.9138	More...