DegronMD

Uniprot ID: O95206

Source protein: Protocadherin-8

Source gene: PCDH8

Class: DEG_SCF_TRCP1_1

Location: 916:922

E3 ligase: BTRC

DEGRON score: 0.9138

ASA_SCORE: 52.0857

COIL: 0.8277

CONS_SCORE: 0.5311

DSS_SCORE: 0.5605

HELIX: 0.0986

FCONS_SCORE: 1.0209

RIG_SCORE: 0.5771

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L917M	DO229032	LICA	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.711
p.V920I	DO222976	BTCA	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.7076
p.Q918K	DO23618	LUAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.6944
p.E922Q	DO15286	HNSC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.6744
p.G920R	TCGA-EE-A29E	SKCM	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	0.6457
p.D921G	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	0.6087
p.D921G	ACH-001498	Lymphoma	CCLE	DSGKGDS	DEG_SCF_TRCP1_1	0.6087
p.D921G	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	0.6087
p.L911P	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	0.3056
p.D926N	TCGA-AP-A1DO	UCEC	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	0.2222
p.D926N	TCGA-B5-A3FA	UCEC	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	0.2222
p.H926L	DO234437	ESAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.2222
p.P912S	DO43186	UCEC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.2222
p.S927N	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	0.1944
p.S927N	ACH-002059	Leukemia	CCLE	DSGKGDS	DEG_SCF_TRCP1_1	0.1944
p.S927N	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	0.1944
p.D928N	TCGA-DF-A2KU	UCEC	TCGA	DSGKGDS	DEG_SCF_TRCP1_1	0.1667
p.Q910K	DO37831	SKCM	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.1667
p.A909V	DO8490	COAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.1389
p.A909T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGKGDS	DEG_SCF_TRCP1_1	0.1389
p.A909T	ACH-002272	Lymphoma	CCLE	DSGKGDS	DEG_SCF_TRCP1_1	0.1389
p.A909T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKGDS	DEG_SCF_TRCP1_1	0.1389
p.Q908L	DO24850	LUAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.1111
p.Y907C	DO38380	STAD	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.0833
p.Y907C	DO43306	UCEC	ICGC	DSGKGDS	DEG_SCF_TRCP1_1	0.0833

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Drug responses associated with PCDH8 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DSGKGDS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95206	Protocadherin-8	DEG_SCF_TRCP1_1	916:922	DSGKGDS	BTRC	0.9138	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGKGDS

Degron related mutations and impact score

Drug responses associated with PCDH8 mutations

All proteins holding degron of DSGKGDS