DegronMD

Uniprot ID: O95206

Source protein: Protocadherin-8

Source gene: PCDH8

Class: DEG_SPOP_SBC_1

Location: 699:703

E3 ligase: SPOP

DEGRON score: 0.9524

ASA_SCORE: 55.14

COIL: 0.4112

CONS_SCORE: 0.4204

DSS_SCORE: 0.3858

HELIX: 0.0102

FCONS_SCORE: 0.8501

RIG_SCORE: 0.748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R697H	TCGA-56-7822	LUSC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.2778
p.R697H	DO26638	LUSC	ICGC	PLTTT	DEG_SPOP_SBC_1	0.2778
p.A704T	TCGA-IB-7651	PAAD	TCGA	PLTTT	DEG_SPOP_SBC_1	0.3056
p.A704T	DO46657	PAAD	ICGC	PLTTT	DEG_SPOP_SBC_1	0.3056
p.D694A	DO48437	BLCA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1944
p.R697G	SIDM00633	Breast Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.2778
p.G695S	SIDM00529	Breast Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.V709M	SIDM01779	Gastric Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.1667
p.V709M	ACH-000761	Gastric Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	0.1667
p.T703N	ACH-000248	Breast Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	0.7055
p.S707T	ACH-000617	Ovarian Cancer	CCLE	PLTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95206	Protocadherin-8	DEG_SPOP_SBC_1	699:703	PLTTT	SPOP	0.9524	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	165:169	PLTTT	SPOP	0.9751	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1755:1759	PLTTT	SPOP	0.8841	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	743:747	PLTTT	SPOP	0.9993	More...
Q53H47	Histone-lysine N-methyltransferase SETMAR	DEG_SPOP_SBC_1	425:429	PLTTT	SPOP	0.5678	More...
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_SPOP_SBC_1	547:551	PLTTT	SPOP	0.5232	More...
Q8ND30	Liprin-beta-2	DEG_SPOP_SBC_1	804:808	PLTTT	SPOP	0.9988	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8776:8780	PLTTT	SPOP	0.9519	More...
Q9HCM2	Plexin-A4	DEG_SPOP_SBC_1	107:111	PLTTT	SPOP	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons