DegronMD

Uniprot ID: Q53H47

Source protein: Histone-lysine N-methyltransferase SETMAR

Source gene: SETMAR

Class: DEG_SPOP_SBC_1

Location: 425:429

E3 ligase: SPOP

DEGRON score: 0.5678

ASA_SCORE: 50.1

COIL: 0.6162

CONS_SCORE: 0.1793

DSS_SCORE: 0.4117

HELIX: 0.2876

FCONS_SCORE: 0.9958

RIG_SCORE: 0.7641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D415Y	TCGA-44-4112	LUAD	TCGA	PLTTT	DEG_SPOP_SBC_1	0.0556
p.D415Y	DO26032	LUAD	ICGC	PLTTT	DEG_SPOP_SBC_1	0.0556
p.N437S	TCGA-FG-8186	LGG	TCGA	PLTTT	DEG_SPOP_SBC_1	0.1111
p.N437S	DO22113	LGG	ICGC	PLTTT	DEG_SPOP_SBC_1	0.1111
p.R430G	DO229054	LICA	ICGC	PLTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95206	Protocadherin-8	DEG_SPOP_SBC_1	699:703	PLTTT	SPOP	0.9524	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	165:169	PLTTT	SPOP	0.9751	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1755:1759	PLTTT	SPOP	0.8841	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	743:747	PLTTT	SPOP	0.9993	More...
Q53H47	Histone-lysine N-methyltransferase SETMAR	DEG_SPOP_SBC_1	425:429	PLTTT	SPOP	0.5678	More...
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_SPOP_SBC_1	547:551	PLTTT	SPOP	0.5232	More...
Q8ND30	Liprin-beta-2	DEG_SPOP_SBC_1	804:808	PLTTT	SPOP	0.9988	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8776:8780	PLTTT	SPOP	0.9519	More...
Q9HCM2	Plexin-A4	DEG_SPOP_SBC_1	107:111	PLTTT	SPOP	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons