DegronMD

Uniprot ID: Q8ND30

Source protein: Liprin-beta-2

Source gene: PPFIBP2

Class: DEG_SPOP_SBC_1

Location: 804:808

E3 ligase: SPOP

DEGRON score: 0.9988

ASA_SCORE: 61.28

COIL: 0.8578

CONS_SCORE: 0.5549

DSS_SCORE: 0.5058

HELIX: 0.071

FCONS_SCORE: 0.9675

RIG_SCORE: 0.7623

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P804Q	TCGA-DU-6392	LGG	TCGA	PLTTT	DEG_SPOP_SBC_1	0.7035
p.R812Q	SIDM00473	Oral Cavity Carcinoma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.2222
p.A798S	SIDM01574	Plasma Cell Myeloma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.1667
p.A798S	SIDM01391	Neuroblastoma	GDSC	PLTTT	DEG_SPOP_SBC_1	0.1667
p.E795Q	TCGA-NK-A5CR	LUSC	TCGA	PLTTT	DEG_SPOP_SBC_1	0.0833

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53H47	Histone-lysine N-methyltransferase SETMAR	DEG_SPOP_SBC_1	425:429	PLTTT	SPOP	0.5678	More...
Q8ND30	Liprin-beta-2	DEG_SPOP_SBC_1	804:808	PLTTT	SPOP	0.9988	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8776:8780	PLTTT	SPOP	0.9519	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1755:1759	PLTTT	SPOP	0.8841	More...
Q9HCM2	Plexin-A4	DEG_SPOP_SBC_1	107:111	PLTTT	SPOP	0.514	More...
O95206	Protocadherin-8	DEG_SPOP_SBC_1	699:703	PLTTT	SPOP	0.9524	More...
P08575	Receptor-type tyrosine-protein phosphatase C	DEG_SPOP_SBC_1	165:169	PLTTT	SPOP	0.9751	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	743:747	PLTTT	SPOP	0.9993	More...
Q8IVB4	Sodium/hydrogen exchanger 9	DEG_SPOP_SBC_1	547:551	PLTTT	SPOP	0.5232	More...

Showing 1 to 9 of 9 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons