DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FTLHME
Uniprot ID:
P07359
Source protein:
Platelet glycoprotein Ib alpha chain
Source gene:
GP1BA
Class:
LIG_APCC_ABBA_1
Location:
363:368
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9035
ASA_SCORE:
103.2333
COIL:
0.8265
CONS_SCORE:
0.3636
DSS_SCORE:
0.584
HELIX:
0.0488
FCONS_SCORE:
1.1363
RIG_SCORE:
0.7657
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F355S
DO233259
GACA
ICGC
FTLHME
LIG_APCC_ABBA_1
0.1111
Drug responses associated with GP1BA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FTLHME
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P07359
Platelet glycoprotein Ib alpha chain
LIG_APCC_ABBA_1
363:368
FTLHME
APC,CDC20,FZR1
0.9035
More...