DegronMD

Uniprot ID: Q52LJ0

Source protein: Protein FAM98B

Source gene: FAM98B

Class: DEG_SPOP_SBC_1

Location: 160:164

E3 ligase: SPOP

DEGRON score: 0.9796

ASA_SCORE: 82.54

COIL: 0.9386

CONS_SCORE: 0.661

DSS_SCORE: 0.3895

HELIX: 0.0418

FCONS_SCORE: 1.0412

RIG_SCORE: 0.7076

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T156A	TCGA-34-5241	LUSC	TCGA	PKSTT	DEG_SPOP_SBC_1	0.2222
p.T156A	DO27341	LUSC	ICGC	PKSTT	DEG_SPOP_SBC_1	0.2222
p.F154C	TCGA-A5-A2K5	UCEC	TCGA	PKSTT	DEG_SPOP_SBC_1	0.1667
p.F154C	DO41379	UCEC	ICGC	PKSTT	DEG_SPOP_SBC_1	0.1667
p.P160H	TCGA-D3-A2JP	SKCM	TCGA	PKSTT	DEG_SPOP_SBC_1	0.7694
p.P160H	DO47407	SKCM	ICGC	PKSTT	DEG_SPOP_SBC_1	0.7694
p.Q173K	TCGA-ET-A39J	THCA	TCGA	PKSTT	DEG_SPOP_SBC_1	0.0833
p.Q173K	DO38956	THCA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.0833
p.P168L	DO233905	GACA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.2222
p.M153I	DO229032	LICA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.1389
p.H169Y	DO230525	LUSC	ICGC	PKSTT	DEG_SPOP_SBC_1	0.1944
p.I159T	DO229253	THCA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.3056
p.D155H	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PKSTT	DEG_SPOP_SBC_1	0.1944
p.D155H	ACH-000326	Leukemia	CCLE	PKSTT	DEG_SPOP_SBC_1	0.1944
p.D155H	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.1944
p.T156I	SIDM00332	Breast Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	0.2222
p.T156I	ACH-001819	Breast Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	0.2222
p.T156I	MFM-223	breast	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SPOP_SBC_1	376:380	PKSTT	SPOP	0.9058	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	1518:1522	PKSTT	SPOP	0.7644	More...
Q52LJ0	Protein FAM98B	DEG_SPOP_SBC_1	160:164	PKSTT	SPOP	0.9796	More...
Q9BZW7	Testis-specific gene 10 protein	DEG_SPOP_SBC_1	89:93	PKSTT	SPOP	0.765	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	515:519	PKSTT	SPOP	0.9463	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	329:333	PKSTT	SPOP	0.828	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1324:1328	PKSTT	SPOP	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons