DegronMD - Q14966(ZNF638)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1446M	TCGA-28-5211	GBM	TCGA	AESSS	DEG_SPOP_SBC_1	1450:1454	Mutation rewiring degron network	0.2222
p.R1446M	DO11016	GBM	ICGC	AESSS	DEG_SPOP_SBC_1	1450:1454	Mutation rewiring degron network	0.2222
p.T612I	TCGA-36-2547	OV	TCGA	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.8189
p.T612I	DO30990	OV	ICGC	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.8189
p.D1485H	TCGA-AC-A23H	BRCA	TCGA	DYR	CBL_MET	1482:1484	Mutation rewiring degron network	0.3056
p.D1485H	DO2401	BRCA	ICGC	DYR	CBL_MET	1482:1484	Mutation rewiring degron network	0.3056
p.S801Y	TCGA-AJ-A3EK	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation blocking phosphorylation signal	0.5
p.S801Y	DO41584	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation blocking phosphorylation signal	0.5
p.S1490Y	TCGA-AP-A059	UCEC	TCGA	DYR	CBL_MET	1482:1484	Mutation rewiring degron network	0.1667
p.S1490Y	DO41361	UCEC	ICGC	DYR	CBL_MET	1482:1484	Mutation rewiring degron network	0.1667
p.R472K	TCGA-B5-A0JY	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.1667
p.R472K	DO43041	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.1667
p.P606Q	TCGA-BF-A1PZ	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.P606Q	DO50279	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.R485Q	TCGA-BS-A0UV	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.25
p.R485Q	TCGA-CA-6718	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.25
p.R485Q	TCGA-EO-A3B0	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.25
p.R485Q	DO7801	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.25
p.R485Q	DO219773	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.25
p.R485Q	DO42793	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.25
p.R485Q	SIDM00438	B-Lymphoblastic Leukemia	GDSC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.25
p.R485Q	ACH-002275	Leukemia	CCLE	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.25
p.R485Q	MN-60	haematopoietic and lymphoid tissue	COSMIC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.25
p.E1512G	TCGA-BT-A3PK	BLCA	TCGA	PKSTT	DEG_SPOP_SBC_1	1518:1522	Mutation rewiring degron network	0.1667
p.E1512G	DO44051	BLCA	ICGC	PKSTT	DEG_SPOP_SBC_1	1518:1522	Mutation rewiring degron network	0.1667
p.Q1460K	TCGA-CN-6010	HNSC	TCGA	AESSS	DEG_SPOP_SBC_1	1450:1454	Mutation rewiring degron network	0.1667
p.Q1460K	DO14766	HNSC	ICGC	AESSS	DEG_SPOP_SBC_1	1450:1454	Mutation rewiring degron network	0.1667
p.P491S	TCGA-DA-A95Z	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.0833
p.P491S	DO219481	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.0833
p.S488C	TCGA-DD-AAD5	LIHC	TCGA	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation blocking phosphorylation signal	0.6111
p.S488C	DO52222	LIHC	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation blocking phosphorylation signal	0.6111
p.P618S	TCGA-EB-A24D	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.P618S	DO37440	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.P618L	TCGA-EB-A24D	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.P618L	DO37440	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.P1518L	TCGA-EB-A5SG	SKCM	TCGA	PKSTT	DEG_SPOP_SBC_1	1518:1522	Mutation altering degron motif	0.7582
p.P1518L	DO48726	SKCM	ICGC	PKSTT	DEG_SPOP_SBC_1	1518:1522	Mutation altering degron motif	0.7582
p.S1526Y	TCGA-EO-A3B0	UCEC	TCGA	PKSTT	DEG_SPOP_SBC_1	1518:1522	Mutation rewiring degron network	0.2222
p.S1526Y	DO219773	UCEC	ICGC	PKSTT	DEG_SPOP_SBC_1	1518:1522	Mutation rewiring degron network	0.2222
p.Q1491K	TCGA-ER-A19N	SKCM	TCGA	DYR	CBL_MET	1482:1484	Mutation rewiring degron network	0.1389
p.Q1491K	DO37452	SKCM	ICGC	DYR	CBL_MET	1482:1484	Mutation rewiring degron network	0.1389
p.R487H	TCGA-FI-A2D5	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.1944
p.R487H	DO41331	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.1944
p.S614N	TCGA-G4-6309	COAD	TCGA	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.818
p.S614N	DO7810	COAD	ICGC	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.818
p.P606S	TCGA-GF-A4EO	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.P606S	DO47559	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.I468L	TCGA-HT-7470	LGG	TCGA	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.0556
p.I468L	DO22209	LGG	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.0556
p.E1451K	TCGA-KQ-A41P	BLCA	TCGA	AESSS	DEG_SPOP_SBC_1	1450:1454	Mutation altering degron motif	0.591
p.E1451K	DO223590	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	1450:1454	Mutation altering degron motif	0.591
p.Q1460H	DO1328	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	1450:1454	Mutation rewiring degron network	0.1667
p.P796S	DO233253	GACA	ICGC	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.1944
p.N474D	DO228585	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.2222
p.A798S	DO229018	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.1389
p.S492I	DO229031	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation blocking phosphorylation signal	0.5
p.G799W	DO229037	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation substituting flanking lysine	0.2222
p.G793V	DO229045	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.2778
p.T1459I	DO232761	PBCA	ICGC	AESSS	DEG_SPOP_SBC_1	1450:1454	Mutation rewiring degron network	0.1944
p.G1476S	DO232224	PBCA	ICGC	DYR	CBL_MET	1482:1484	Mutation rewiring degron network	0.1667
p.A798D	SIDM01281	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.1389
p.R486T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.2222
p.R486T	ACH-000924	Lung Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.2222
p.R486T	NCI-H2172	lung	COSMIC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.2222
p.Y1483C	SIDM00582	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	1482:1484	Mutation altering degron motif	0.7087
p.Y1483C	ACH-000281	Pancreatic Cancer	CCLE	DYR	CBL_MET	1482:1484	Mutation altering degron motif	0.7087
p.Y1483C	KP-2	pancreas	COSMIC	DYR	CBL_MET	1482:1484	Mutation altering degron motif	0.7087
p.R487C	SIDM01080	Oral Cavity Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.1944
p.R487C	SCC-9	upper aerodigestive tract	COSMIC	RKENE	DEG_APCC_KENBOX_2	478:482	Mutation rewiring degron network	0.1944
p.R1524S	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	1518:1522	Mutation rewiring degron network	0.2778
p.R1524S	ACH-000861	Lung Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	1518:1522	Mutation rewiring degron network	0.2778
p.R1524S	HOP-62	lung	COSMIC	PKSTT	DEG_SPOP_SBC_1	1518:1522	Mutation rewiring degron network	0.2778
p.S605L	SIDM01577	Plasma Cell Myeloma	GDSC	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation blocking phosphorylation signal	0.6389
p.S605L	ACH-000889	Myeloma	CCLE	PKTSS	DEG_SPOP_SBC_1	610:614	Mutation blocking phosphorylation signal	0.6389
p.E785D	SIDM01588	Endometrial Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.2778
p.E785D	ACH-000993	Endometrial/Uterine Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.2778
p.S1462G	ACH-000494	Non-Cancerous	CCLE	AESSS	DEG_SPOP_SBC_1	1450:1454	Mutation blocking phosphorylation signal	0.5556
p.A780S	ACH-000539	Non-Cancerous	CCLE	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.1389
p.T1487R	ACH-001458	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	1482:1484	Mutation rewiring degron network	0.25
p.A792T	ACH-002069	Bone Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.3056
p.A778S	NCI-H847	lung	COSMIC	VTSTS	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF638

UniProt ID: Q14966

Entrez ID: 27332

Protein name: Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF638 in