DegronMD

Uniprot ID: Q14966

Source protein: Zinc finger protein 638

Source gene: ZNF638

Class: DEG_APCC_KENBOX_2

Location: 478:482

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7217

ASA_SCORE: 133.34

COIL: 0.8014

CONS_SCORE: 0.7502

DSS_SCORE: 0.7549

HELIX: 0.1928

FCONS_SCORE: 1.0534

RIG_SCORE: 0.5593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R472K	TCGA-B5-A0JY	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1667
p.R472K	DO43041	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1667
p.R485Q	TCGA-BS-A0UV	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.25
p.R485Q	TCGA-CA-6718	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.25
p.R485Q	TCGA-EO-A3B0	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.25
p.R485Q	DO7801	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.25
p.R485Q	DO219773	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.25
p.R485Q	DO42793	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.25
p.R485Q	SIDM00438	B-Lymphoblastic Leukemia	GDSC	RKENE	DEG_APCC_KENBOX_2	0.25
p.R485Q	ACH-002275	Leukemia	CCLE	RKENE	DEG_APCC_KENBOX_2	0.25
p.R485Q	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.25
p.P491S	TCGA-DA-A95Z	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	0.0833
p.P491S	DO219481	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	0.0833
p.S488C	TCGA-DD-AAD5	LIHC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.6111
p.S488C	DO52222	LIHC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.6111
p.R487H	TCGA-FI-A2D5	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1944
p.R487H	DO41331	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1944
p.I468L	TCGA-HT-7470	LGG	TCGA	RKENE	DEG_APCC_KENBOX_2	0.0556
p.I468L	DO22209	LGG	ICGC	RKENE	DEG_APCC_KENBOX_2	0.0556
p.N474D	DO228585	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2222
p.S492I	DO229031	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.5
p.R486T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.2222
p.R486T	ACH-000924	Lung Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	0.2222
p.R486T	NCI-H2172	lung	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.2222
p.R487C	SIDM01080	Oral Cavity Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.1944
p.R487C	SCC-9	upper_aerodigestive_tract	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14966	Zinc finger protein 638	DEG_APCC_KENBOX_2	478:482	RKENE	APC,CDC20,FZR1	0.7217	More...
Q15170	Transcription elongation factor A protein-like 1	DEG_APCC_KENBOX_2	5:9	RKENE	APC,CDC20,FZR1	0.9469	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_APCC_KENBOX_2	856:860	RKENE	APC,CDC20,FZR1	0.9466	More...
Q8IUC8	Polypeptide N-acetylgalactosaminyltransferase 13	DEG_APCC_KENBOX_2	447:451	RKENE	APC,CDC20,FZR1	0.5702	More...
Q8N3J5	Protein phosphatase 1K, mitochondrial	DEG_APCC_KENBOX_2	104:108	RKENE	APC,CDC20,FZR1	0.9571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENE

Degron related mutations and impact score

Drug responses associated with ZNF638 mutations

All proteins holding degron of RKENE