DegronMD - Q8IUC8(GALNT13)

FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (PubMed:12407114, PubMed:22186971). Generates GalNAc-O-Ser/Thr structure also known... View more >>

GO - Biological processes (BP): O-glycan processing [GO:0016266]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]

GO - Molecular function (MF): carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]

GO - Cellular component (CC): Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S511F	DO222418	MELA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.7982
p.R447L	TCGA-55-8205	LUAD	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7316
p.R447L	DO48884	LUAD	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7316
p.R447H	TCGA-EI-6917	READ	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.R447H	DO222884	COCA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.R447H	DO36881	READ	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.R447H	SIDM00216	Colorectal Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.R447H	ACH-000989	Colon/Colorectal Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.H516R	ACH-001853	Bile Duct Cancer	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.7133
p.E449K	DO220878	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	DO220899	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	DO220913	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	DO222402	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	DO229456	SKCA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	SIDM01059	Melanoma	GDSC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	ACH-000915	Skin Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	IPC-298	skin	COSMIC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.V515L	DO228986	LICA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.6765
p.T513R	ACH-000554	Breast Cancer	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.6765
p.T513R	UACC-893	breast	COSMIC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.6765

Showing 1 to 20 of 67 entries

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Kaplan plot for GALNT13 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

GALNT13

UniProt ID: Q8IUC8

Entrez ID: 114805

Protein name: Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GALNT13 in