DegronMD - Q8IUC8(GALNT13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R447S	TCGA-05-4417	LUAD	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.6316
p.R447S	DO23570	LUAD	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.6316
p.Q440L	TCGA-17-Z022	LUAD	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.1389
p.R515Q	TCGA-31-1950	OV	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.6218
p.R515Q	DO30980	OV	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.6218
p.E451K	TCGA-3N-A9WC	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.591
p.E451K	TCGA-RP-A694	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.591
p.E451K	DO51269	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.591
p.E451K	DO51234	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.591
p.E451K	SIDM00545	Melanoma	GDSC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.591
p.E451K	ACH-000987	Skin Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.591
p.E451K	Mewo	skin	COSMIC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.591
p.P526T	TCGA-44-2655	LUAD	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1111
p.P526T	DO23557	LUAD	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1111
p.E510D	TCGA-55-7907	LUAD	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.5647
p.E510D	DO25396	LUAD	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.5647
p.R447L	TCGA-55-8205	LUAD	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7316
p.R447L	DO48884	LUAD	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7316
p.Q440H	TCGA-A6-6138	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.1389
p.Q440H	DO10427	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.1389
p.G501V	TCGA-AX-A2HC	UCEC	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.0833
p.G501V	DO41572	UCEC	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.0833
p.S527F	TCGA-B5-A0JY	UCEC	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.0833
p.S527F	DO43041	UCEC	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.0833
p.K452N	TCGA-C8-A12K	BRCA	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.3056
p.K452N	DO1258	BRCA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.3056
p.G501A	TCGA-CJ-6033	KIRC	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.0833
p.G501A	DO16881	KIRC	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.0833
p.D524H	TCGA-DU-7300	LGG	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1667
p.D524H	DO22684	LGG	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1667
p.D443Y	TCGA-EE-A184	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.2222
p.D443Y	DO47442	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.2222
p.D443Y	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.2222
p.R447H	TCGA-EI-6917	READ	TCGA	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.R447H	DO222884	COCA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.R447H	DO36881	READ	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.R447H	SIDM00216	Colorectal Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.R447H	ACH-000989	Colon/Colorectal Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7133
p.G501R	TCGA-Q9-A6FW	ESCA	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.0833
p.L523I	DO222421	BTCA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1944
p.T438S	DO227549	COCA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.0833
p.E437K	DO222688	ESCA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.0556
p.E437K	SIDM01175	Other Sarcomas	GDSC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.0556
p.E437K	ACH-002309	Sarcoma	CCLE	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.0556
p.E437K	SW684	soft tissue	COSMIC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.0556
p.V515L	DO228986	LICA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.6765
p.M445I	DO229036	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.2778
p.E449K	DO220878	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	DO220899	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	DO220913	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	DO222402	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	DO229456	SKCA	ICGC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	SIDM01059	Melanoma	GDSC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	ACH-000915	Skin Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.E449K	IPC-298	skin	COSMIC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation altering degron motif	0.7022
p.S511F	DO222418	MELA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.7982
p.G501E	DO222880	MELA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.0833
p.D508N	DO219878	SKCA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.2778
p.M445V	SIDM00535	Chondrosarcoma	GDSC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.2778
p.M445V	ACH-001519	Bone Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.2778
p.M445V	H-EMC-SS	bone	COSMIC	RKENE	DEG_APCC_KENBOX_2	447:451	Mutation rewiring degron network	0.2778
p.N520S	ACH-000534	Lymphoma	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.2778
p.N520S	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.2778
p.T513R	ACH-000554	Breast Cancer	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.6765
p.T513R	UACC-893	breast	COSMIC	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.6765
p.N518S	ACH-001610	Brain Cancer	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.5958
p.H516R	ACH-001853	Bile Duct Cancer	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.7133

Kaplan plot for GALNT13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GALNT13

UniProt ID: Q8IUC8

Entrez ID: 114805

Protein name: Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GALNT13 in