DegronMD

Uniprot ID: Q8IUC8

Source protein: Polypeptide N-acetylgalactosaminyltransferase 13

Source gene: GALNT13

Class: DEG_APCC_KENBOX_2

Location: 447:451

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5702

ASA_SCORE: 107.28

COIL: 0.9212

CONS_SCORE: 0.4561

DSS_SCORE: 0.2556

HELIX: 0.012

FCONS_SCORE: 0.7381

RIG_SCORE: 0.7803

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R447S	TCGA-05-4417	LUAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.6316
p.R447S	DO23570	LUAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.6316
p.Q440L	TCGA-17-Z022	LUAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1389
p.E451K	TCGA-3N-A9WC	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	0.591
p.E451K	TCGA-RP-A694	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	0.591
p.E451K	DO51269	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	0.591
p.E451K	DO51234	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	0.591
p.E451K	SIDM00545	Melanoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.591
p.E451K	ACH-000987	Skin Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	0.591
p.E451K	Mewo	skin	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.591
p.R447L	TCGA-55-8205	LUAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.7316
p.R447L	DO48884	LUAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7316
p.Q440H	TCGA-A6-6138	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1389
p.Q440H	DO10427	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1389
p.K452N	TCGA-C8-A12K	BRCA	TCGA	RKENE	DEG_APCC_KENBOX_2	0.3056
p.K452N	DO1258	BRCA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.3056
p.D443Y	TCGA-EE-A184	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	0.2222
p.D443Y	DO47442	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2222
p.D443Y	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.2222
p.R447H	TCGA-EI-6917	READ	TCGA	RKENE	DEG_APCC_KENBOX_2	0.7133
p.R447H	DO222884	COCA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7133
p.R447H	DO36881	READ	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7133
p.R447H	SIDM00216	Colorectal Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.7133
p.R447H	ACH-000989	Colon/Colorectal Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	0.7133
p.T438S	DO227549	COCA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.0833
p.E437K	DO222688	ESCA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.0556
p.E437K	SIDM01175	Other Sarcomas	GDSC	RKENE	DEG_APCC_KENBOX_2	0.0556
p.E437K	ACH-002309	Sarcoma	CCLE	RKENE	DEG_APCC_KENBOX_2	0.0556
p.E437K	SW684	soft_tissue	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.0556
p.M445I	DO229036	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2778
p.E449K	DO220878	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7022
p.E449K	DO220899	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7022
p.E449K	DO220913	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7022
p.E449K	DO222402	MELA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7022
p.E449K	DO229456	SKCA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7022
p.E449K	SIDM01059	Melanoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.7022
p.E449K	ACH-000915	Skin Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	0.7022
p.E449K	IPC-298	skin	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.7022
p.M445V	SIDM00535	Chondrosarcoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.2778
p.M445V	ACH-001519	Bone Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	0.2778
p.M445V	H-EMC-SS	bone	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14966	Zinc finger protein 638	DEG_APCC_KENBOX_2	478:482	RKENE	APC,CDC20,FZR1	0.7217	More...
Q15170	Transcription elongation factor A protein-like 1	DEG_APCC_KENBOX_2	5:9	RKENE	APC,CDC20,FZR1	0.9469	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_APCC_KENBOX_2	856:860	RKENE	APC,CDC20,FZR1	0.9466	More...
Q8IUC8	Polypeptide N-acetylgalactosaminyltransferase 13	DEG_APCC_KENBOX_2	447:451	RKENE	APC,CDC20,FZR1	0.5702	More...
Q8N3J5	Protein phosphatase 1K, mitochondrial	DEG_APCC_KENBOX_2	104:108	RKENE	APC,CDC20,FZR1	0.9571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENE

Degron related mutations and impact score

Drug responses associated with GALNT13 mutations

All proteins holding degron of RKENE