DegronMD

Uniprot ID: Q8N3J5

Source protein: Protein phosphatase 1K, mitochondrial

Source gene: PPM1K

Class: DEG_APCC_KENBOX_2

Location: 104:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9571

ASA_SCORE: 80.38

COIL: 0.7654

CONS_SCORE: 0.5604

DSS_SCORE: 0.3317

HELIX: 0.1636

FCONS_SCORE: 1.1721

RIG_SCORE: 0.7824

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A98T	TCGA-5M-AAT4	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A98T	TCGA-AZ-6598	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A98T	TCGA-R6-A6DN	ESCA	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A98T	DO10276	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A98T	DO223702	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A98T	SIDM00305	Ovarian Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A98T	SIDM00220	Ovarian Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A98T	ACH-001145	Ovarian Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A98T	ACH-001513	Cervical Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A98T	JHOS-2	ovary	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.1667
p.R110L	TCGA-AP-A1E0	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.2778
p.R110L	DO43154	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2778
p.R110W	TCGA-DU-6392	LGG	TCGA	RKENE	DEG_APCC_KENBOX_2	0.2778
p.R110W	DO22237	LGG	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2778
p.A114V	TCGA-FI-A2D5	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A114V	DO41331	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1667
p.E106K	TCGA-FR-A69P	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	0.7022
p.E106K	DO47292	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7022
p.G102A	TCGA-P3-A6SX	HNSC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.2778
p.G102A	DO49051	HNSC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2778
p.A114T	DO9876	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1667
p.A114T	DO23258	LINC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1667
p.F113L	DO229022	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1944
p.D112E	DO229026	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2222
p.D112E	DO229045	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2222
p.A104D	DO229031	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.7793
p.A106V	DO43186	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.6936
p.A106V	DO52402	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.6936
p.A106V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.6936
p.R104W	SIDM02035	Colorectal Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	0.7523
p.R104W	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RKENE	DEG_APCC_KENBOX_2	0.7523
p.G102S	ACH-001645	Skin Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	0.2778
p.A104T	CAL-51	breast	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14966	Zinc finger protein 638	DEG_APCC_KENBOX_2	478:482	RKENE	APC,CDC20,FZR1	0.7217	More...
Q15170	Transcription elongation factor A protein-like 1	DEG_APCC_KENBOX_2	5:9	RKENE	APC,CDC20,FZR1	0.9469	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_APCC_KENBOX_2	856:860	RKENE	APC,CDC20,FZR1	0.9466	More...
Q8IUC8	Polypeptide N-acetylgalactosaminyltransferase 13	DEG_APCC_KENBOX_2	447:451	RKENE	APC,CDC20,FZR1	0.5702	More...
Q8N3J5	Protein phosphatase 1K, mitochondrial	DEG_APCC_KENBOX_2	104:108	RKENE	APC,CDC20,FZR1	0.9571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENE

Degron related mutations and impact score

Drug responses associated with PPM1K mutations

All proteins holding degron of RKENE