DegronMD - Q5TCQ9(MAGI3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G863D	TCGA-06-5416	GBM	TCGA	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.25
p.G863D	DO10880	GBM	ICGC	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.25
p.A664S	TCGA-78-7536	LUAD	TCGA	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation rewiring degron network	0.1667
p.A664S	DO26414	LUAD	ICGC	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation rewiring degron network	0.1667
p.L854S	TCGA-AA-3977	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.2778
p.L854S	DO8730	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.2778
p.D669Y	TCGA-AP-A1DK	UCEC	TCGA	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation rewiring degron network	0.3056
p.D669Y	DO42033	UCEC	ICGC	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation rewiring degron network	0.3056
p.P683H	TCGA-AX-A1CE	UCEC	TCGA	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation rewiring degron network	0.0833
p.P683H	DO42280	UCEC	ICGC	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation rewiring degron network	0.0833
p.T1458I	TCGA-B5-A0JY	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.1111
p.T1458I	DO43041	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.1111
p.T868A	TCGA-BR-7707	STAD	TCGA	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.1111
p.T868A	DO38487	STAD	ICGC	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.1111
p.E1440Q	TCGA-CR-6472	HNSC	TCGA	PESSS	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.1667
p.E1440Q	DO15870	HNSC	ICGC	PESSS	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.1667
p.S1450Y	TCGA-EI-6917	READ	TCGA	PESSS	DEG_SPOP_SBC_1	1446:1450	Mutation altering degron motif	0.8231
p.S1450Y	DO36881	READ	ICGC	PESSS	DEG_SPOP_SBC_1	1446:1450	Mutation altering degron motif	0.8231
p.R856Q	TCGA-FS-A1ZC	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation altering degron motif	0.6218
p.R856Q	DO37487	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation altering degron motif	0.6218
p.T868I	TCGA-W3-AA1V	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.1111
p.T868I	DO51276	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.1111
p.E858D	DO8264	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation altering degron motif	0.6758
p.D851N	DO228890	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.1944
p.V852F	DO229006	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.2222
p.D1436N	DO220903	MELA	ICGC	PESSS	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.0556
p.E672K	DO232056	ORCA	ICGC	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation altering degron motif	0.7022
p.G675E	DO229459	SKCA	ICGC	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation rewiring degron network	0.3056
p.K662Q	SIDM00238	Ovarian Carcinoma	GDSC	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation substituting flanking lysine	0.2222
p.K662Q	ACH-000947	Ovarian Cancer	CCLE	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation substituting flanking lysine	0.2222
p.K662Q	OVK-18	ovary	COSMIC	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation substituting flanking lysine	0.2222
p.R1443K	SIDM01660	Kidney Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.25
p.R1443K	ACH-000709	Kidney Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.25
p.T853K	NB12	autonomic ganglia	COSMIC	RKENE	DEG_APCC_KENBOX_2	856:860	Mutation rewiring degron network	0.25
p.R679I	NCI-H1568	lung	COSMIC	KKENA	DEG_APCC_KENBOX_2	670:674	Mutation rewiring degron network	0.1944

Kaplan plot for MAGI3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGI3

UniProt ID: Q5TCQ9

Entrez ID: 260425

Protein name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAGI3 in