DegronMD

Uniprot ID: Q5TCQ9

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Source gene: MAGI3

Class: DEG_APCC_KENBOX_2

Location: 670:674

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9539

ASA_SCORE: 113.14

COIL: 0.786

CONS_SCORE: 0.4152

DSS_SCORE: 0.6316

HELIX: 0.1694

FCONS_SCORE: 0.7908

RIG_SCORE: 0.6693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A664S	TCGA-78-7536	LUAD	TCGA	KKENA	DEG_APCC_KENBOX_2	0.1667
p.A664S	DO26414	LUAD	ICGC	KKENA	DEG_APCC_KENBOX_2	0.1667
p.D669Y	TCGA-AP-A1DK	UCEC	TCGA	KKENA	DEG_APCC_KENBOX_2	0.3056
p.D669Y	DO42033	UCEC	ICGC	KKENA	DEG_APCC_KENBOX_2	0.3056
p.P683H	TCGA-AX-A1CE	UCEC	TCGA	KKENA	DEG_APCC_KENBOX_2	0.0833
p.P683H	DO42280	UCEC	ICGC	KKENA	DEG_APCC_KENBOX_2	0.0833
p.E672K	DO232056	ORCA	ICGC	KKENA	DEG_APCC_KENBOX_2	0.7022
p.G675E	DO229459	SKCA	ICGC	KKENA	DEG_APCC_KENBOX_2	0.3056
p.K662Q	SIDM00238	Ovarian Carcinoma	GDSC	KKENA	DEG_APCC_KENBOX_2	0.2222
p.K662Q	ACH-000947	Ovarian Cancer	CCLE	KKENA	DEG_APCC_KENBOX_2	0.2222
p.K662Q	OVK-18	ovary	COSMIC	KKENA	DEG_APCC_KENBOX_2	0.2222
p.R679I	NCI-H1568	lung	COSMIC	KKENA	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15596	Nuclear receptor coactivator 2	DEG_APCC_KENBOX_2	739:743	KKENA	APC,CDC20,FZR1	0.856	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_APCC_KENBOX_2	670:674	KKENA	APC,CDC20,FZR1	0.9539	More...
Q969Z4	Tumor necrosis factor receptor superfamily member 19L	DEG_APCC_KENBOX_2	234:238	KKENA	APC,CDC20,FZR1	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons